50461-59-1

Basic information

• Product Name: 2',3',5',6'-TETRAHYDRO-1'H-[3,4']BIPYRIDINYL-4'-OL
• Synonyms: 4-pyridin-3-ylpiperidin-4-ol(SALTDATA: 2HCl H2O);4-Pyridin-3-ylpiperidin-4-ol dihydrochloride;4-(3-Pyridinyl)-4-piperidinol 2HCl;4-(3-pyridyl)-4-piperidinol;4-(3-pyridyl)piperidin-4-ol;4-(Pyridin-3-yl);4-(3-Pyridinyl)-4-piperidinol;2',3',5',6'-TETRAHYDRO-1'H-[3,4']BIPYRIDINYL-4'-OL
• CAS NO: 50461-59-1
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.23
• Product Categories: pharmacetical
• Mol File: 50461-59-1.mol

Chemical Properties

• Boiling Point: 345°C at 760 mmHg
• Flash Point: 162.4°C
• Appearance: /
• Density: 1.147g/cm³
• Vapor Pressure: 2.41E-05mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 13.45±0.20(Predicted)
• CAS DataBase Reference: 2',3',5',6'-TETRAHYDRO-1'H-[3,4']BIPYRIDINYL-4'-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2',3',5',6'-TETRAHYDRO-1'H-[3,4']BIPYRIDINYL-4'-OL(50461-59-1)
• EPA Substance Registry System: 2',3',5',6'-TETRAHYDRO-1'H-[3,4']BIPYRIDINYL-4'-OL(50461-59-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 50461-59-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2',3',5',6'-TETRAHYDRO-1'H-[3,4']BIPYRIDINYL-4'-OL is used as a building block for the synthesis of various organic compounds, contributing to the development of new pharmaceuticals. Its unique molecular structure and potential biological activities make it a valuable component in creating innovative drugs.
Used in Organic Synthesis:
In the field of organic synthesis, 2',3',5',6'-TETRAHYDRO-1'H-[3,4']BIPYRIDINYL-4'-OL is utilized as a key intermediate for the production of a wide range of organic compounds. Its versatile chemical properties allow it to be incorporated into various synthetic pathways, facilitating the creation of novel molecules with diverse applications.

InChI:InChI=1/C10H14N2O/c13-10(3-6-11-7-4-10)9-2-1-5-12-8-9/h1-2,5,8,11,13H,3-4,6-7H2

Upstream product

• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 95798-23-5 1-(benzyloxycarbonyl)-4-hydroxypiperidine 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 188879-36-9 1'-benzyl-2',3',5',6'-tetrahydro-1'H-[3,4']bipyridinyl-4'-ol 

Downstream Products

• 1021202-89-0 N-(2-(2-(4-hydroxy-4-(pyridin-3-yl)piperidin-1-yl)-2-oxoethoxy)ethyl)-4-methoxy-N,2,6-trimethylphenylsulfonamide 
• 1021202-73-2 1-(4'-hydroxy-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-yl)-2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-ethanone 
• 1021203-38-2 1-(4'-hydroxy-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-yl)-2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-pyrrolidin-2-ylmethoxy]-ethanone 
• 1021201-51-3 2,4,6-trichloro-N-{2-[2-(4'-hydroxy-3',4',5',6'-tetrahydro-2'H-[3,4']bipyridinyl-1'-yl)-2-oxo-ethoxy]-ethyl}-N-methyl-phenylsulfonamide 
• 1191240-34-2 tert-butyl 4-hydroxy-4-(pyridin-3-yl)piperidine-1-carboxylate 
• 1242848-68-5 1-(4-hydroxy-4-pyridin-3-ylpiperidin-1-yl)-2-[2-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]ethanone 

Relevant articles and documents

Substituted Disulfonamide Compounds

Substituted disulfonamide compounds corresponding to formula I: In which R1, R2, R3, R4a, R4b, R5a, R5b, R8, R9a, R9b, R10, R11, a, b, s, t and A have defined meanings, pharmaceutical compositions containing one or more such compounds, processes for preparing such compounds, and a method of using such compounds for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin receptor 1 (BR1).

Substituted Pyrimidine and Triazine Compounds

Substituted pyrimidine and triazine compounds corresponding to formula I wherein R1, R2, R3, R4a, R4b, R5a, R5b, R7, R8, R9a, R9b, R10, R11, A, a, b, s, t, V, W1, W2 and W3 have defined meanings, pharmaceutical compositions comprising such compounds, a process for preparing such compounds, and the use of such compounds and compositions to treat or inhibit pain and/or other disorders or disease states.

Substituted Indole Compounds

Substituted indole compounds corresponding to the formula I: In which R8, R9a, R9b, R10, R11, R200, R210, A, D, T, q, s and t have defined meanings, processes for the preparation thereof, pharmaceutical compositions containing such compounds and the use of substituted indole compounds for the treatment or inhibition of pain and other conditions which are at least partly mediated by Bradykinin 1 receptors (B1R).

Substituted Sulfonamide Compounds

Substituted sulfonamide compounds with bradykinin receptor (B1R) modulating activity; processes for the preparation thereof, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or inhibit pain and/or other disorders and/or disease states.

INDAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF

The present invention can provide a cancer treatment drug containing, as an active ingredient, a substance selected from the group consisting of an indazole compound of the following formula (I), a pharmaceutically acceptable salt, a hydrate, a water adduct and a solvate:

METHANOANTHRACENEYL METHYL PIPERIDINYL COMPOUNDS

Compounds of formula I or I', STR1 wherein X and Y are independently selected from hydrogen, halo, and (1-6C)alkoxy;R 1 is selected from(A) (1-6C)alkyl; (B) phenyl and naphthyl or substituted versions thereof; (C) phenyl (1-3C)alkyl and naphthyl (1-3C) alkyl;(D) five-and six-membered heteroaryl rings;(E) heteroaryl (1-3C) alkyl and pharmaceutically acceptable salts thereof, useful in the treatment of neuropsychiatric disorders such as psychoses; pharmaceutical compositions comprising a compound of formula I or I' and a pharmaceutically acceptable diluent or carrier; and methods of treating neuropsychiatric disorders comprising administering to a mammal (including man) in need of such treatment an effective amount of a compound of formula I or I', or a pharmaceutically acceptable salt thereof are claimed. The invention also relates to novel processes for producing enantiomeric methanoanthracenyl sulfoxides.