50461-86-4

Usage

Uses

Used in Pharmaceutical Industry:
Hesperetin is used as a therapeutic agent for its potential health benefits, including antioxidant, anti-inflammatory, and anti-cancer properties. It has been studied for its potential in the treatment and prevention of cardiovascular diseases and diabetes, as well as improving cognitive function and reducing the risk of neurodegenerative diseases.
Used in Functional Foods and Supplements:
Hesperetin is used as a functional ingredient in foods and supplements to provide consumers with its health-promoting properties. Its antioxidant and anti-inflammatory effects can contribute to overall well-being and support a healthy lifestyle.
Used in Cosmetics and Skincare Products:
Hesperetin is used in cosmetics and skincare products for its potential anti-aging and skin health benefits. Its antioxidant properties can help protect the skin from environmental damage and promote a youthful appearance.
Used in Research and Development:
Hesperetin is used in research and development for its potential applications in various fields, including pharmaceuticals, nutraceuticals, and cosmetics. Ongoing studies aim to further explore its health-promoting properties and develop novel formulations and delivery systems to enhance its efficacy and bioavailability.

InChI:InChI=1/C19H18O8/c1-23-10-7-5-9(6-8-10)15-18(25-3)13(21)11-12(20)17(24-2)14(22)19(26-4)16(11)27-15/h5-8,20,22H,1-4H3

Upstream product

• 1150-40-9 1,3-dimethoxy-2,4,6-trinitrobenzene 
• 1201-06-5 1,3,5-trihydroxy-2,4-dimethoxybenzene 
• 151-10-0 1,3-Dimethoxybenzene 
• 1756-88-3 1,3,5-triamino-2,4-dimethoxybenzene 
• 1630-09-7 2,4-dichloro-1,3,5-trinitrobenzene 
• 176662-13-8 7-Benzyloxy-3-hydroxy-5,6,8-trimethoxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 176662-06-9 1-(2,4-diacetoxy-3,5,6-trimethoxyphenyl)ethanone 
• 56002-85-8 1-benzyloxy-2,3,5,6-tetramethoxybenzene 
• 176662-07-0 1-(2-Hydroxy-3,5,6-trimethoxy-4-methoxymethoxy-phenyl)-ethanone 
• 56002-84-7 2,3,5,6-tetramethoxyphenyl acetate 
• 73213-66-8 7-hydroxy-5,6,8,4′-tetramethoxyflavone 
• 56002-81-4 1,2-dihydroxy-3,4,6-trimethoxybenzene 
• 7507-98-4 1-(2-hydroxy-3,4,6-trimethoxyphenyl)ethanone 
• 56002-82-5 2,3-diacetoxy-1,4,5-trimethoxy-benzene 

Relevant academic research and scientific papers

Studies of the Selective O-Alkylation and Dealkylation of Flavonoids. XXI.: A Convenient Method for Synthesizing 3,5,7-Trihydroxy-6,8-dimethoxyflavones and 5,7-Dihydroxy-3,6,8-trimethoxyflavones

The Friedel-Crafts acetylation with boron trifluoride was studied and it was found that 1-(2,4-dihydroxy-3,5,6-trimethoxyphenyl)ethanone was conveniently synthesized from 2,3,5,6-tetramethoxyphenyl acetate in a mixture of acetic anhydride and acetic acid. 1-[2-Hydroxy-3,5,6-trimethoxy-4-(methoxyinethoxy)phenyl]ethanone was cyclized to 7-hydroxy-5,6,8-trimethoxyflavone by using the Baker-Venkataraman transformation. The 7-benzyl ether of the flavone was oxidized with dimethyldioxirane and then treated with a small amount of p-toluenesulfonic acid to give 7-benzyloxy-3-hydroxy-5,6,8-trimethoxyflavone, which was converted into the methyl ether and tosylate. The 5-methoxy group in the methyl ether or tosylate was selectively cleaved with anhydrous aluminum bromide in acetonitrile under mild conditions to give the corresponding 5-hydroxyflavones and the latter compound with a 3-tosyloxy group was smoothly converted into the 3,5-dihydroxyflavone by hydrolysis with potassium carbonate in methanol. The hydrogenolysis of the 7-benzyloxy-3,5-dihydroxyflavone and its 3-methyl ether afforded quantitatively 3,5,7-trihydroxy-6,8-dimethoxyflavone and its 3-methyl ether. The process was suitable as a general method for synthesizing 3,5,7-trihydroxy-6,8-dimethoxyflavones and their 3-methyl ethers and the six flavones were synthesized for the clarification of their 1H and 13CNMR, MS, and UV spectral properties.

Synthesis of Araneol and Araneosol, the Flavonoids of Anaphalis araneosa DC

Araneol (5,7-dihydroxy-3,6,8-trimethoxyflavone, I) and araneosol (5,7-dihydroxy-3,6,8,4'-tetramethoxyflavone, II) have been synthesised by Hoesch condensation of 1,3,5-trihydroxy-2,4-dimethoxybenzene (III) with methoxyacetonitrile, followed by Allan-Robin