85950-49-8

Upstream product

• 1738-36-9 2-methoxyacetonitrile 
• 1201-06-5 1,3,5-trihydroxy-2,4-dimethoxybenzene 
• 1150-40-9 1,3-dimethoxy-2,4,6-trinitrobenzene 
• 1756-88-3 1,3,5-triamino-2,4-dimethoxybenzene 
• 151-10-0 1,3-Dimethoxybenzene 
• 1630-09-7 2,4-dichloro-1,3,5-trinitrobenzene 

Downstream Products

• 50461-86-4 5,7-dihydroxy-3,6,8,4′-tetramethoxyflavone 
• 71479-92-0 5,7-dihydroxy-3,6,8-trimethoxyflavone 
• 2033-89-8 3,4-dimethoxyphenol 
• 113744-04-0 5,7-dihydroxy-3,6,8,2',4',5'-hexamethoxyflavone 

Relevant academic research and scientific papers

An Unusual O-Methylation in the Allan-Robinson Synthesis of Purpurascenin, a 3,5,6,7,8,2',4',5'-Octamethoxyflavone

In the Allan-Robinson synthesis of 3,5,6,7,8,2',4',5'-octamethoxyflavone (Purpurascenin, I), from 2,4,6-trihydroxy-3,5,ω-trimethoxyacetophenone (IV) and asarylic anhydride, the expected intermediate, 5,7-dihydroxy-3,6,8,2',4',5'-hexamethoxyflavone (III) unusually gets further methylated to give 5-hydroxy-3,6,7,8,2',4',5'-heptamethoxyflavone (II) during the course of reaction.The possible mechanism of methylation is discussed.

Synthesis of Araneol and Araneosol, the Flavonoids of Anaphalis araneosa DC

Araneol (5,7-dihydroxy-3,6,8-trimethoxyflavone, I) and araneosol (5,7-dihydroxy-3,6,8,4'-tetramethoxyflavone, II) have been synthesised by Hoesch condensation of 1,3,5-trihydroxy-2,4-dimethoxybenzene (III) with methoxyacetonitrile, followed by Allan-Robin