50465-25-3Relevant articles and documents
Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus
Li, Jin-Long,Wu, Lei,Wu, Jian,Feng, Hong-Xuan,Wang, Hong-Min,Fu, Yan,Zhang, Ru-Jun,Zhang, Hai-Yan,Zhao, Wei-Min
, p. 2774 - 2779 (2016/12/06)
Three new triterpenoids, celastrusins A-C (1-3), together with 3-O-caffeoyl-α-amyrin (4) were isolated from the root bark of Celastrus orbiculatus. Their structures were identified by spectroscopic analysis, X-ray crystallography using Cu Kα radiation, and the comparison of both observed and reported spectroscopic data. An in vitro bioassay revealed that the caffeoyl triterpenoid esters 1, 3, and 4 possess neuroprotective effects against oxygen-glucose deprivation (OGD) induced SH-SY5Y cell damage. Further animal studies indicated that compound 1 significantly reduced brain infarction after transient middle cerebral artery occlusion (MCAO) in rats using a 10 mg/kg (i.v.) dose.
21α,30-DIHYDROXY-D:A-FRIEDOOLEANAN-3-ONE FROM SALACIA RETICULATA VAR. β-DIANDRA STEM BARK
Kumar, Vijaya,Wijeratne, Dharmashree B. T.,Abeygunawardena, Chitrananda
, p. 333 - 335 (2007/10/02)
Salacia reticulata var. β-diandra stem bark contained 21α,30-dihydroxy-D:A-friedooleanan-3-one and eight other D:A-friedooleananes.