50469-21-1

Basic information

• Product Name: 4,7-Dioxo-4,7-dihydro-1H-indole-3-carboxylic acid
• Synonyms: 4,7-Dioxo-4,7-dihydro-1H-indole-3-carboxylic acid
• CAS NO: 50469-21-1
• Molecular Formula: C9H5NO4
• Molecular Weight: 191.1403
• Mol File: 50469-21-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4,7-Dioxo-4,7-dihydro-1H-indole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4,7-Dioxo-4,7-dihydro-1H-indole-3-carboxylic acid(50469-21-1)
• EPA Substance Registry System: 4,7-Dioxo-4,7-dihydro-1H-indole-3-carboxylic acid(50469-21-1)

Safety Data

• Hazardous Substances Data: 50469-21-1(Hazardous Substances Data)

Upstream product

• 78942-74-2 4,7-dihydroxyindole-3-carboxylic acid 
• 23876-39-3 4,7-dimethoxylindole 
• 78942-76-4 4,7-dimethoxyindole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Carboxylation and Acylation of 4,7-Dimethoxyindoles and a Study of the Corresponding Dealkylated Derivatives

Treatment of 4,7-dimethoxyindoles 1 and 9 with ethylmagnesium bromide and ethyl chloroformate in refluxing dry ether gives the corresponding indole-1-carboxylic acid ethyl esters 3 and 10 as major products, together, with minor amounts of indole-3-carboxylic acid ethyl esters 2 and 11.Similar treatment of 4,7-dimethoxyindole(1) with ethylmagnesium bromide and chloroacetyl chloride affords the related 3-chloroacetyl derivative 13.All of the new 4,7-dimethoxyindole compounds were dealkylated with anhydrous aluminium chloride in refluxing dry benzene.Transformation of these demethylated indoles into other interesting derivatives, in view of possible antimicrobial activity is also reported.