50470-25-2

Upstream product

• 1105107-53-6 2,3,3,3-tetrafluoro-2-trimethylsiloxypropiophenone 
• 111269-36-4 3-phenyl-1,1,1-trifluoropropane-2,3-dione 3-dimethylhydrazone 

Downstream Products

• 220248-46-4 1,1,1-trifluoro-3-hydrazono-3-phenyl-propan-2-one 
• 914081-10-0 4-trifluoromethyl-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione 
• 914080-99-2 4-trifluoromethyl-6,8-dimethyl-3-phenyl-5,6,7,8-tetrahydropyrimido[4,5-c]pyridazine-5,7-dione 
• 914081-04-2 4-trifluoromethyl-4-hydroxy-6,8-dimethyl-3-phenyl-1,4,5,6,7,8-hexahydropyrimido[4,5-c]pyridazine-5,7-dione 
• 260445-59-8 3,3,3-trifluoro-1-phenyl-propane-1,2-dione 1-oxime 

Relevant academic research and scientific papers

Reductive modification of difluoromethylene moiety in pentafluoropropionyl group

The reductive Mg-promoted defluorinative-silylation of 2,2,3,3,3-pentafluoropropiophenone readily produces the α-trifluoromethyl enol silyl ether, which then react with electrophiles to give a variety of 2-substituted-3,3,3-trifluoropropiophenones in excellent yields. The same protocol is applicable for the preparation of enol silyl ether of 3,3,3-trifluoropropiophenone. Fluoride ion catalyzed 1,2-desilylative-defluorination of 2,3,3,3-tetrafluoro-2-trimethylsilyloxypropiophenone provided 3,3,3-trifluoro-1-phenyl-1,2-propanedione in a good yield.

A convenient synthesis of 4,5-bis(trifluoromethyl)pyridazines

Acid catalyzed selfcondensation of 3-hydrazono-1,1,1 trifluoroalkan-2-ones (2) prepared from 1,1,1-trifIuoroalkan-2,3-diones (1) and 100% hydrazine hydrate afforded 4,5-bis(trifluoromethyl)pyridazines (3) in satisfactory yields.