50471-17-5

Usage

Type of compound

Heterocyclic compound

Structure

Contains a benzisoxazole ring and an acetonitrile group

Usage

Building block in organic synthesis and pharmaceutical research

Applications

Development of new drugs, treatment of medical conditions (mental health disorders, neurological diseases)

Investigated properties

Antimicrobial and anticancer properties

Field of relevance

Medicinal chemistry

InChI:InChI=1/C9H6N2O/c10-6-5-8-7-3-1-2-4-9(7)12-11-8/h1-4H,5H2

Upstream product

• 37924-85-9 3-bromomethyl-1,2-benzisoxazole 
• 151-50-8 potassium cyanide 

Downstream Products

• 88137-22-8 (Z)-2-(1,2-benzisoxazol-3-yl)-3-<2-(2-morpholinoethoxy)phenyl>acrylonitrile 
• 82625-26-1 (Z)-2-(1,2-benzisoxazol-3-yl)-3-<2-(2-chloroethoxy)phenyl>acrylonitrile 
• 81821-84-3 (Z)-2-Benzo[d]isoxazol-3-yl-3-[2-(3-chloro-propoxy)-phenyl]-acrylonitrile 
• 344765-97-5 (Z)-2-Benzo[d]isoxazol-3-yl-3-[4-(2-chloro-ethoxy)-phenyl]-acrylonitrile 
• 82625-28-3 (Z)-2-Benzo[d]isoxazol-3-yl-3-[4-(3-chloro-propoxy)-phenyl]-acrylonitrile 
• 131074-16-3 Benzo[d]isoxazol-3-yl-phenylazo-acetonitrile 
• 344765-96-4 (Z)-2-Benzo[d]isoxazol-3-yl-3-[3-(2-chloro-ethoxy)-phenyl]-acrylonitrile 
• 81821-83-2 (Z)-2-Benzo[d]isoxazol-3-yl-3-[2-(4-chloro-butoxy)-phenyl]-acrylonitrile 
• 82625-27-2 (Z)-2-Benzo[d]isoxazol-3-yl-3-[3-(3-chloro-propoxy)-phenyl]-acrylonitrile 
• 59916-23-3 2-benzo[d]isoxazol-3-yl-N-hydroxy-N'-phenyl-acetamidine 
• 59899-86-4 3-(5-phenyl-[1,2,4]oxadiazol-3-ylmethyl)-benzo[d]isoxazole 
• 50471-13-1 2-benzo[d]isoxazol-3-yl-N-benzoyloxy-acetamidine 
• 59899-85-3 (3-benzo[d]isoxazol-3-ylmethyl-[1,2,4]thiadiazol-5-yl)-phenyl-amine 
• 55985-59-6 N-(2-benzo[d]isoxazol-3-yl-acetimidoyl)-O-(3-phenyl-acryloyl)-hydroxylamine 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

α-Bromoacetophenones in Heterocyclic Synthesis: A Convenient One-Pot Synthesis and the Chemical Behaviour of 3-Bromomethylbenzoisoxazole

A novel one-pot synthesis of 3-bromomethylbenzoisoxazole (3) utilizing o-hydroxy-α-bromoacetophenone is reported.Coupling of 3 with benzenediazonium chloride afforded, the first reported, C-(3-benzoisoxazolyl)-N-(phenyl)formohydrazidoyl bromide (13).The chemical behaviour of 3 and 13 towards a variety of chemical reagents has been investigated.