50472-09-8

Upstream product

• 2785-98-0 2,5-dimethoxybenzoic acid 
• 26002-58-4 2,5-dimethoxy-6-nitrobenzamide 
• 1056955-99-7 2-acetoxy-5-methoxy-benzoic acid methyl ester 
• 1206-55-9 3,6-dimethoxy-2-nitrobenzaldehyde 
• 89229-48-1 6-hydroxy-3-methoxy-2-nitrobenzoic acid 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 50472-10-1 2-amino-3,6-dimethoxybenzoic acid 
• 50425-26-8 3,6-dimethoxy-2-nitrobenzoyl chloride 
• 121625-10-3 2-Carboxy-3,6-dimethoxy-benzenediazonium; chloride 
• 1616295-05-6 2-cyclopropyl-5,8-dimethoxy-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-quinazoline 
• 1616296-07-1 C₂₁H₂₃ClN₄O₃ 
• 102888-94-8 3,6-dimethoxy-2-(4-nitro-benzylamino)-benzoic acid-(4-nitro-benzyl ester) 
• 121625-00-1 3,6-dimethoxyl-2-methylbenzaldehyde 
• 854736-96-2 N-[2-(hydroxymethyl)phenyl]-3,6-dimethoxy-2-nitrobenzamide 
• 854736-98-4 N-(2-formylphenyl)-3,6-dimethoxy-2-nitrobenzamide 
• 912342-26-8 2,5-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile 

Relevant academic research and scientific papers

SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1

Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Synthesis of (+/-)-puraquinonic acid: an inducer of cell differentiation.

Puraquinonic acid (1) was synthesized from 2,5-dimethoxybenzoic acid by way of isochroman 2 and the indanone derivative 3, a Nazarov cyclization being used to construct the five-membered ring.

Synthesis of a pyrrolo[1,4]benzodiazepinequinone

Condensation of 3,6-dimethoxy-2-nitrobenzoyl chloride with L-proline methyl ester afforded amide 4, which underwent reductive cyclization with iron(II) sulfate and ammonium hydroxide to yield pyrrolobenzodiazepine 5. Oxidation of 5 with ammonium cerium(IV

Rearrangement Reactions of Bicyclic Systems. Part V. Acid-catalysed Rearrangements of 1,4-Dihydro-1,5,8-trimethoxy-1,4-ethenonaphthalene and the Remarkable Effect of Aromatic Methoxy-groups on the Course of the Reaction

3,6-Dimethoxyanthranilic acid (2) has been prepared by a procedure that is more reliable than our earlier one and used as a 3,6-dimethoxybenzyne precursor in a reaction with anisole to give 1,4-dihydro-1,5,8-trimethoxy-1,4-ethenonaphthalene (1,5,8-trimeth

3,6-DIMETHOXYBENZOCYCLOBUTENONE: A REAGENT FOR QUINONE SYNTHESIS

3,6-Dimethoxybenzocyclobutenone 4 is prepared in four efficient steps from 2,5-dimethoxybenzoic acid 8.The derived benzocyclobutenol 13 undergoes electrocyclic ring opening at 110-115 deg C to give the hydroxy-o-quinone dimethide 21, which reacts with dienophiles to give 5,8-dimethoxy-1,2,3,4-tetrahydro-1-naphthol derivatives stereoselectively.Since the ketone 4 can be functionalised at C-5 using electrophiles and at C-2 via homolytic bromation, the ring opening and cycloaddition sequence offers a flexible route to linear fused hydroquinone and quinone derivatives.In model studies, the benzocyclobutenol derivative 48 underwent thermal electrocyclic ring opening and intramolecular cycloaddition to give 49, while the analogous reaction with 52 failed due to adverse steric effects during the cycloaddition step.In photochemical experiments, attempts to generate the silyl ether 57 by in situ silylation of the dienol 55 and to prepare the benzocyclobutenol 62 via irradiation of the o-phthalaldehyde monoacetal 60 were unsuccessful.