50483-74-4

Upstream product

• 104-85-8 para-methylbenzonitrile 
• 5852-49-3 5-phenyl-1,3,4-oxathiazol-2-one 
• 622-47-9 4-tolylacetic acid 
• 1670-14-0 benzamidine monohydrochloride 
• 104-82-5 4-Methylbenzyl chloride 
• 104-81-4 4-Methylbenzyl bromide 

Relevant academic research and scientific papers

A copper-catalyzed approach for the synthesis of asymmetrical disubstituted 1,2,4-thiadiazoles via elemental sulfur-mediated decarboxylative redox cyclization

The variety of asymmetrical disubstituted 1,2,4-thiadiazoles are smoothly prepared by copper-catalyzed approach, which employed arylacetic acids and amidines as substrates, and elemental sulfur to mediate decarboxylative redox cyclization. The advantages of this method are simple, efficient, and ligand-free. In addition, this method can provide products in moderate to good yields.

Method for synthesizing 1,2,4-thiadiazole derivative

The invention relates to a method for synthesizing a 1,2,4-thiadiazole derivative, and belongs to the technical field of chemical preparation. The method comprises the following steps: taking and dissolving a phenylacetic acid compound and a benzylamidine hydrochloride compound in an organic solvent according to a mass ratio of (1-2):1, adding a catalyst, an oxidant and an alkaline medium, and stirring at 130-140 DEG C for 18-24 h to react in order to obtain the 1,2,4-thiadiazole derivative; and cooling, extracting, drying, evaporating under reduced pressure to remove the solvent, and carryingout column chromatography to obtain the pure product. The method for synthesizing thiadiazole has the following advantages: (1) the reaction conditions are mild, the product selectivity is high, andthe substrate expansion range is wide; and (2) the used raw materials are low in price and cost, and the reaction operation is simple, safe and convenient.

An alternatively metal-free synthesis of 1,3,5-triazines or 1,2,4-thiadiazoles from benzyl chlorides and benzylamines mediated by elemental sulfur

An elemental sulfur mediated reaction of benzyl chlorides with benzylamines is developed, which allows the practical synthesis of valuable 1,3,5-triazines. This protocol that is metal free, ligand free, and uses inexpensive elemental sulfur as oxidant or raw material displays mild reaction conditions, a broad substrate scope and moderate to good yields. Moreover, the modified sulfur-mediated reaction system can also be used to synthesize 1,2,4-thiadiazoles, by simply switching the stoichiometry of sulfur powder from 0.75 equivalents to 5 equivalents.

Multicomponent reactions (MCRs) of arylmethyl bromides, arylamidines and elemental sulfur toward unsymmetric 3,5-diaryl 1,2,4-thiadiazoles

A base-promoted three-component reaction between arylmethyl bromides, arylamidines and elemental sulfur was developed, leading to unsymmetric 3,5-diaryl-1,2,4-thiadiazoles in moderate to good yields with chemical diversity and complexity. This procedure shows broad substrates scope by employing elemental sulfur and commercially available starting materials under transition-metal free conditions.