50488-14-7

Upstream product

• 108-31-6 maleic anhydride 
• 919-30-2 3-aminopropyltriethoxysilane 

Downstream Products

• 29602-11-7 N-(3-triethoxysilylpropyl)maleimide 

Relevant academic research and scientific papers

LCD-based detection of enzymatic action

By incorporating an ester-containing substrate in a self-assembled alignment layer for liquid crystal cells, the presence of a lipase (CALB) can be directly detected through its enzymatic action on the alignment layer, without the need for fluorescent lab

Isomerization in the reaction of (aminoalkyl)trialkoxysilanes with carboxylic acid anhydrides

The products of the reactions of monofunctional (3-aminopropyl) triethoxysilane and (3-aminopropyl)trimethoxysilane and bifunctional [3-N-(2-aminoethyl)aminopropyl]trimethoxysilane with acetic and maleic anhydrides in CCl4 at varied reagent molar ratios are studied by 1H and 13C NMR spectroscopy. It is shown that the reaction of [3-N-(2-aminoethyl)aminopropyl]trimethoxysilane with the above anhydrides leads to formation of diamides as mixtures of cisoid and transoid rotamers about both amide bonds. The reactions with monofunctional (aminopropyl) trialkoxysilanes give individual isomers.

A molecular nanocap activated by superparamagnetic heating for externally stimulated cargo release

A novel thermoresponsive snaptop for stimulated cargo release from superparamagnetic iron oxide core - mesoporous silica shell nanoparticles based on a [2 + 4] cycloreversion reaction (retro-Diels Alder reaction) is presented. The non-invasive external actuation through alternating magnetic fields makes this material a promising candidate for future applications in externally triggered drug delivery.

Thermoreversible reactions on inorganic nanoparticle surfaces: Diels-alder reactions on sterically crowded surfaces

Organically surface-functionalized nanoparticles are important cross-linkers for nanocomposites. In the past, many cross-linking reactions were based on simple radical additions. However, novel smart materials require reversible reactions. These reactions, such as the Diels-Alder reaction, often have a specific sterical demand, e.g., a six-centered transition state. In this study, 5 nm silica particles were functionalized with maleimide groups, and their reactivity with regard to Diels-Alder reactions were investigated, applying various techniques. A new method for the surface modification of silica nanoparticles is presented, minimizing agglomeration in organic solvents and thus increasing the accessibility of the functional groups on the particle surface. Kinetic studies of substituted model compounds were carried out to evaluate the reactivity of the maleimide functionality. The Diels-Alder reaction between 2,5-dimethylfuran and N-propylmaleimide, N-ethyl(N-propylcarbamato) maleimide, and N-phenylmaleimide was followed by UV/Vis spectroscopy. The reaction rate increases in this order, showing the effect of maleimide substitution. Afterwards N-((3-triethoxysilyl)propyl)maleimide was used to graft maleimidopropyl functional groups onto the nanoparticle surface. 3-Aminopropyltriethoxysilane, which could then be reacted with 1,1′-(methylenedi-4,1-phenylene)bismaleimide, was used to attach phenyl-substituted maleimide functionality to the surface. 3- Isocyanatopropyltriethoxysilane introduced the electron-drawing carbamato functionality into the system. The surface coverage of the samples was characterized applying CHN analysis, TGA-FTIR coupling, and FTIR spectroscopy. All analytical methods revealed that the functional groups are covalently bonded to the silica surface and the maleimide rings remain intact. Diels-Alder reactions of the surface groups show that the reactivity of the molecules attached to the particles depends on sterical crowding, but the reaction rate is not significantly changed by surface effects.

Studies on the attachment of DNA to silica-coated nanoparticles through a Diels-Alder reaction

A new method has been investigated for the functionalization of gold nanoparticles with DNA. Silica-coated nanoparticles functionalized with a maleimide have been prepared. These particles are designed to react with modified DNA containing a diene functionality at one end of the molecule. The result would be the formation of a more stable attachment of the DNA to the particle through a Diels-Alder reaction. This covalent attachment would not be susceptible to ligand exchanges, which are known to occur in the conventional DNA functionalization of gold nanoparticles. Copyright Taylor & Francis, Inc.

Reaction of organosilicon amines with dicarboxylic anhydrides

Organosilicon amines react with cyclic dicarboxylic anhydrides to form previously unknown amido acids, which are converted into ammonium salts by the reaction with an equimolar amount of the amine. The structures of the compounds were studied by NMR spectroscopy.