50488-89-6

Usage

Uses

Used in Pharmaceutical Industry:
Aloe-emodin-3-(hydroxymethyl)-O-β-D-glucopyranoside is used as a potential therapeutic agent for its anti-inflammatory properties, making it a candidate for treating skin disorders and other inflammation-related conditions.
Used in Nutraceutical Industry:
Due to its antioxidant capabilities, Aloe-emodin-3-(hydroxymethyl)-O-β-D-glucopyranoside is utilized as a component in health supplements to support overall wellness and combat oxidative stress.
Used in Oncology Research:
Aloe-emodin-3-(hydroxymethyl)-O-β-D-glucopyranoside is employed as a subject of research in oncology for its anticancer effects, with potential applications in the development of novel cancer treatments.
Used in Digestive Health Applications:
Given its presence in aloe vera, which is traditionally known for its soothing effects on the digestive system, Aloe-emodin-3-(hydroxymethyl)-O-β-D-glucopyranoside is studied for its potential role in managing digestive problems.

Upstream product

• 133-89-1 UDP-glucose 
• 481-72-1 1,8-dihydroxy-3-hydroxymethyl-9,10-anthracenedione 

Relevant academic research and scientific papers

Investigations to mechanism and applications of the glycosylation protocol employing 8-methyltosylaminoethynyl-1-naphthyl (MTEAN) glycoside donors

Based on the capability of silyl ethers for efficient glycosylation, the new MTEAN glycosylation protocol utilizing 8-methyltosylaminoethynyl-1-naphthyl (MTEAN) glycosides as donors were extended to one-pot synthesis of nucleosides, late-stage modification of bioactive molecules, and stereoselective construction of 1,2-cis-glucosidic linkages using silyl ethers of the acceptors. Moreover, the reaction mechanism was systematically investigated by control reactions and side product characterizations, leading to the determination of a TfOH-catalyzed ynamide functionality-initiated process, which was further corroborated by identifications of the departure form of leaving group and the real catalyst.

Two trifunctional leloir glycosyltransferases as biocatalysts for natural products glycodiversification

Two promiscuous Bacillus licheniformis glycosyltransferases, YdhE and YojK, exhibited prominent stereospecific but nonregiospecific glycosylation activity of 20 different classes of 59 structurally different natural and non-natural products. Both enzymes transferred various sugars at three nucleophilic groups (OH, NH2, SH) of diverse compounds to produce O-, N-, and S-glycosides. The enzymes also displayed a catalytic reversibility potential for a one-pot transglycosylation, thus bestowing a cost-effective application in biosynthesis of glycodiversified natural products in drug discovery.