481-72-1 Usage
Physical and Chemical Properties
Aloe emodin aloe is one the major components of the aloe essential oils. It is either presented in aloe in the free form or presented in rhubarb, senna, and aloe in the form of glycosides. The compound precipitated from toluene or ethanol is yellow-orange needles with a relative molecular mass of 270.25 and the melting point of 223~224 ℃. It can be subject to sublimation in the carbon dioxide gas stream. It is easily soluble in hot ethanol, ether, benzene, with the solution exhibiting yellow color. It is also soluble in aqueous ammonia and sulfuric acid with the solution exhibiting crimson color.
The main active ingredient of aloe is the barbaloin and aloe emodin. The aloe juice has anti-inflammatory effect and can promote healing of skin damage.
The above information is edited by the lookchem of Dai Xiongfeng.
Rhubarb
Rhubarb is a kind of commonly used traditional Chinese medicine. It was initially recorded in the "Shen Nong's Herbal Classic", low-grade product. It is recorded in every generations of Ancient herbal medicine. Rhubarb is the Polygonaceae plant rhubarb Rheum, Rheum tanguticum and the dried roots or rhizomes of medicinal rhubarb Rheum officinale Baill. It is mainly produced in Sichuan, Gansu, Qinghai and other places. Rhubarb has effects such as purge heating and intestine cleaning, blood cooling and detoxification effect, and blood stasis dredging and can be applied to the treatment of the internal heating and constipation, Indigestion, abdominal pain, diarrhea, heat jaundice, vomiting blood, red eyes, swollen throat, abdominal pain, appendicitis, carbuncle swollen boils, blood stasis amenorrhea, and bruises. It can also be applied to external treatment of fire burns, upper gastrointestinal bleeding and so on. We can apply it with raw use or wine-processing, wine steaming or fried carbon.
Rhubarb has inhibitory effect on most Gram-positive bacteria as well as some Gram-negative bacteria in vitro. Its main active ingredient is anthraquinone derivative with the aloe emodin, emodin and rhein yielding the best efficacy.
It has inhibition on the murine leukemia P388: people extracted rhein, emodin and aloe emodin from rhubarb. These three kinds of anthraquinone can all reduce the number of cancer cells and the amount of ascites in tumor mice with different extent, in which the effect of rhein is the most significant and the effect of aloe emodin is relatively poor; the effect is generally correlated with the prolonged survival period. Emodin, rhein has a strong inhibitory effect on the biosynthesis of DNA, RNA and protein while aloe emodin strong has a weak inhibitory effect.
Figure 1 Rheum officinale Baill.
Chemical Properties
Orange Solid
Uses
Different sources of media describe the Uses of 481-72-1 differently. You can refer to the following data:
1. Shows significant inhibitory activity against the P-388 leukemia in mice when administered as a suspension in acetone-Tween 80. Has a specific in vitro and in vivo antineuroectodermal tumor activity. Cathartic.
2. Aloe-emodin has been used as a standard in high performance liquid chromatography (HPLC) for separation and identification of phenolic compounds in Aloe arborescens Miller var. natalensis Berger (Kidachi aloe).
3. Aloe-emodin may be used as an analytical reference standard for the determination of the analyte in plant and animal samples by high-performance liquid chromatography technique.
Definition
ChEBI: A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.
General Description
Diacerein is known to be a suitable drug to treat osteoarthritis and prevent vascular diseases. It is a semi-synthetic anthraquinone derivative which acts by inhibiting the production of interleukin-1 and secretion of metalloproteases.
Biochem/physiol Actions
Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.
Check Digit Verification of cas no
The CAS Registry Mumber 481-72-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 481-72:
(5*4)+(4*8)+(3*1)+(2*7)+(1*2)=71
71 % 10 = 1
So 481-72-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
481-72-1Relevant articles and documents
Studies in Anthracycline Synthesis: SImple Diels-Alder Routes to Pachybasin, ω-Hydroxypachybasin, Aloe-emodin, and Fallacinol
Benfaremo, Nicholas,Cava, Michael P.
, p. 139 - 141 (1985)
-
An efficient total synthesis of chrysophanol and the sennoside C aglycon
Kuhnert, Nikolai,Molod, Hoshiar Y.
, p. 7571 - 7573 (2005)
A rapid synthetic approach to the naturally occurring chrysophanol and the sennoside C aglycon is reported. The method involves a three-step protocol starting with commercially available aloin-A to give the two title compounds.
-
Seel
, p. 229,234 (1919)
-
Inducing apoptosis through upregulation of p53: structure–activity exploration of anthraquinone analogs
Agbowuro, Ayodeji A.,Anifowose, Abiodun,Lu, Wen,Tan, Chalet,Tripathi, Ravi,Wang, Binghe,Yang, Xiaoxiao
, p. 1199 - 1210 (2020/06/17)
We previously reported a series of p53-elevating anthraquinone compounds with considerable cytotoxicity for acute lymphoblastic leukemia (ALL) cells. To further develop this class of compounds, we examined the effect of a few key structural features on the anticancer structure–activity relationship (SAR) in ALL cells. The active analogs showed comparable cytotoxicity and upregulation of p53 but did not induce significant downregulation of MDM2 as seen with the lead compound AQ-101, indicating the importance of the anthraquinone core scaffold for MDM2 regulation. The result from the current study not only contributes to the SAR framework of these anthraquinone derivatives but also opens up new chemical space for further optimization work.
Synthesis of (-)-Flavoskyrins by Catalyst-Free Oxidation of (R)-Configured Dihydroanthracenones in Aqueous Media and Its (Bio)synthetic Implications
Mondal, Amit,De, Arijit,Husain, Syed Masood
, p. 8511 - 8515 (2020/11/12)
A catalyst-free method for the synthesis of dimeric (-)-flavoskyrins has been developed. It involves the autoxidation of chemoenzymatically synthesized (R)-configured dihydroanthracenones in the presence of molecular oxygen in buffer of pH 6.0 followed by spontaneous [4 + 2] cycloaddition in stereocontrolled exo-anti fashion to form (-)-flavoskyrins. The method is applied to obtain several homo- A s well as heterodimerized flavoskyrins (nine examples) in 27-72% yield and implies the involvement of a similar pathway in the (bio)synthesis of modified bisanthraquinones and their analogues.
