50493-12-4

Basic information

• Product Name: 3-phenyl-2H-benzo[h]chromen-2-one
• CAS NO: 50493-12-4
• Molecular Formula: C₁₉H₁₂O₂
• Molecular Weight: 272.2974
• Mol File: 50493-12-4.mol

Chemical Properties

• Boiling Point: 495.6°C at 760 mmHg
• Flash Point: 209.8°C
• Density: 1.276g/cm³
• Vapor Pressure: 5.83E-10mmHg at 25°C
• Refractive Index: 1.695
• CAS DataBase Reference: 3-phenyl-2H-benzo[h]chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-2H-benzo[h]chromen-2-one(50493-12-4)
• EPA Substance Registry System: 3-phenyl-2H-benzo[h]chromen-2-one(50493-12-4)

Safety Data

• Hazardous Substances Data: 50493-12-4(Hazardous Substances Data)

Upstream product

• 574-96-9 1-hydroxy-2-naphthaldehyde 
• 4638-79-3 2-chloro-2-phenylacetaldehyde 
• 100-52-7 benzaldehyde 
• 1004-99-5 2-chloro-2-phenylethanol 
• 96-09-3 styrene oxide 
• 1071203-70-7 3-Chloro-4-methoxy-3-phenyl-3,4,5,6-tetrahydro-benzo[h]chromen-2-one 
• 2912-62-1 α-chlorophenylacetyl chloride 
• 87937-63-1 3-Phenyl-5,6-dihydro-7,8-benzocoumarin 

Relevant articles and documents

A copper-catalyzed three component reaction of aryl acetylene, sulfonyl azide and enaminone to form iminolactone via 6π electrocyclization

We developed a copper-catalyzed three component reaction of aryl acetylene, enaminone and sulfonyl azide to construct iminolactone via a cascade process involving copper-catalyzed alkyne-azide cycloaddition (CuAAC), Michael addition of metalated ketenimin

Synthesis of 3-arylcoumarins through N-heterocyclic carbene catalyzed condensation and annulation of 2-chloro-2-arylacetaldehydes with salicylaldehydes

The condensation reaction of 2-chloro-2-arylacetaldehyde with salicylaldehyde catalyzed by N-heterocyclic carbene (NHC) leading to 3-arylcoumarin was studied. A number of 3-arylcoumarin derivatives were obtained in good to excellent yields via this umpolung reaction. This reaction is facile and experimentally simple and mild.

Synthesis of 3-substituted coumarins from 2-(acyloxy)arylaldehydes using the TiCl4/R3N reagent system

3-Substituted coumarins are formed in 37-63% yields by the reaction of 2-(acyloxy)arylaldehydes with the TiC4/R3N reagent system. The structure of the compound 2c was determined by single crystal X-ray analysis.

(4 + 2) Cycloaddition of Ketenes and β-Methoxy α,β-Unsaturated Ketones: 2-Pyranones

The cycloaddition of diphenyl- and various chloroketenes to β-methoxy α,β-unsaturated ketones afforded (4 + 2) cycloaddition products.The cycloadducts resulting from the chloroketenes were converted to 2-pyranones on treatment with zinc in moist acetic acid.The cycloaddition products from chloroketenes and β-(methoxymethylene)-α-tetralone were readily converted to substituted benzocoumarins.