50505-95-8

Upstream product

• 637-44-5 phenylpropyolic acid 
• 98-86-2 acetophenone 
• 647833-19-0 1-(1H-benzo[d]-[1,2,3]triazol-1-yl)-3-phenylprop-2-yn-1-one 

Downstream Products

• 22542-40-1 2-phenyl-1-(5-phenyl-1⁽²⁾H-pyrazol-3-yl)-ethanone hydrazone 
• 1029-94-3 2,6-diphenyl-pyran-4-one 
• 146882-14-6 5-Phenyl-2-[1-phenyl-meth-(E)-ylidene]-furan-3-one 

Relevant academic research and scientific papers

Gold-Catalyzed Oxidative Cyclization Involving Nucleophilic Attack to the Keto Group of α,α′-Dioxo Gold Carbene and 1,2-Alkynyl Migration: Synthesis of Furan-3-carboxylates

A multicomponent strategy for the synthesis of functionalized furan-3-carboxylates based on gold-catalyzed oxidative cyclization of diynones with alcohols or water has been developed. Mechanistic studies revealed that a rare nucleophilic attack to the carbonyl group of the α,α′-dioxo gold carbene instead of the carbene center and 1,2-alkynyl group migration were involved in this transformation. This method offers several advantages such as mild conditions, high regio- and chemoselectivity, and wide functional group compatibility.