505062-53-3Relevant academic research and scientific papers
Silica-supported sodium sulfonate with ionic liquid: A neutral catalyst system for Michael reactions of indoles in water
Gu, Yanlong,Ogawa, Chikako,Kobayashi, Shu
, p. 175 - 178 (2007)
(Chemical Equation Presented) A neutral catalytic system for Michael reactions of indoles has been developed by combining silica-supported benzenesulfonic acid sodium salt with hydrophobic ionic liquid in water. An efficient hydrophobic environment could
Alkylation of Indoles with α,β-Unsaturated Ketones using Alumina in Hexanes
Zhang, Xiong,Jones-Mensah, Ebenezer,Deobald, Jackson,Magolan, Jakob
supporting information, p. 5548 - 5551 (2019/11/19)
We evaluated the influence of solvent on the alumina-promoted C3-alkylation of indoles with α,β-unsaturated ketones. We found that lipophilic solvents were generally superior to hydrophilic ones with hexanes offering the 3-alkyl indole products in high yields. Thus, we demonstrate an inexpensive and procedurally simple new process that pairs acidic alumina with hexanes to achieve this important Michael alkylation. The substrate scope includes twenty-four examples with reaction yields ranging from 61 to 96%. (Figure presented.).
Bismuth nitrate-catalyzed michael reactions of indoles in water
Banik, Bimal K.,Garcia, Isabella,Morales, Frances R.
, p. 919 - 924 (2008/03/13)
A remarkable and simple bismuth nitrate-catalyzed Michael reaction of indoles with 1,2-unsaturated ketones in water has been developed to reduce the complications that characterize the current standard conditions.
Iodine-catalyzed highly efficient Michael reaction of indoles under solvent-free condition
Banik, Bimal K.,Fernandez, Miguel,Alvarez, Clarissa
, p. 2479 - 2482 (2007/10/03)
Michael reaction of indoles with unsaturated ketones has been accomplished in the presence of catalytic amount of iodine under solvent-free condition.
Bismuth nitrate-catalyzed versatile Michael reactions
Srivastava, Neeta,Banik, Bimal K.
, p. 2109 - 2114 (2007/10/03)
Bismuth nitrate-catalyzed versatile Michael reaction was developed to reduce the complications that characterize the current standard Michael reaction and used for facile preparation of organic compounds of widely different structures. For example, several substituted amines, imidazoles, thio compounds, indoles, and carbamates were prepared at room temperature by following this method. In contrast with the existing methods using many acidic catalysts, this method is very general, simple, high-yielding, environmentally friendly, and oxygen and moisture tolerant. However, the promoting role of bismuth nitrate in this reaction is not understood at this time.
