505068-18-8

Usage

Chemical structure

A derivative of piperazine with a propylsulfonyl substituent.

Applications

Commonly used in the synthesis of pharmaceuticals and agrochemicals, as well as in the manufacture of polymers and other industrial chemicals.

Biological activity

Has potential anti-inflammatory and antiproliferative properties.

Drug discovery

Identified as a potential ligand for various protein targets, making it of interest for drug discovery and development.

Versatility

Unique chemical structure makes it a versatile building block for the synthesis of diverse organic molecules.

Importance

Its potential biological activity and versatility underscore its importance in medicinal chemistry and chemical biology.

Upstream product

• 110-85-0 piperazine 
• 10147-36-1 n-propanesulfonyl chloride 
• 120-43-4 4-ethoxycarbonylpiperazine 
• 913952-86-0 tert-butyl 4-(propylsulfonyl)piperazine-1-carboxylate 
• 1132825-82-1 4-(propane-1-sulfonyl)-piperazine-1-carboxylic acid ethyl ester 

Downstream Products

• 428830-45-9 1-nitrobenzyl-4-propylsulfonyl piperazine 
• 929891-72-5 4-((4-(propylsulfonyl)piperazin-1-yl)methyl)aniline 
• 1132825-27-4 4-[6-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-N-{4-[4-(propane-1-sulfonyl)-piperazin-1-ylmethyl]-phenyl}-benzamide 
• 1351674-84-4 N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide 
• 1351672-51-9 2-chloro-N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-6-(trifluoromethoxy)benzamide hydrochloride 
• 1351672-27-9 2,6-dichloro-N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)benzamide hydrochloride 
• 1351672-22-4 N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,6-difluorobenzamide hydrochloride 
• 1351672-29-1 C₂₃H₃₄F₃N₃O₄S*ClH 
• 1351673-32-9 N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-2,4-bis(trifluoromethyl)benzamide hydrochloride 
• 1351672-43-9 2-chloro-N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-4-(trifluoromethyl)benzamide hydrochloride 
• 1351672-46-2 2-chloro-N-((4,4-difluoro-1-(4-(propylsulfonyl)piperazin-1-yl)cyclohexyl)methyl)-4-fluorobenzamide hydrochloride 

Relevant academic research and scientific papers

Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates bearing sulfonylpiperazine as antitumor inhibitors targeting PI3Kα

PI3K signal pathway plays a vital role in cellular functions and becomes an attractive approach for cancer therapy. Herein, a new series of novel chromeno[4,3-c]pyrazol-4(2H)-one derivatives bearing sulfonylpiperazine based on the PI3K inhibitors and our previous research. They were screened for their PI3K inhibitory activities and anticancer effects in vitro. Biological studies indicated that compound 7m revealed the remarkable antiproliferative activity (IC50 ranging from 0.03 to 0.09 μM) against four cancer cell lines (A549, Huh7, HL60 and HCT-116). Besides, compound 7m displayed a certain selective for PI3Kα (IC50 = 0.009 μM) over PI3Kβ, γ and δ, and meanwhile, it can remarkable decreased the expression level of p-Akt (Ser473) and p-S6K. In addition, compound 7m could not only induce HCT-116 cell arrest at G1 phase in a dose-dependent manner, but also induce cell apoptosis via upregulation of Bax and cleaved-caspase 3/9, and downregulation of Bcl-2. Besides, compound 7m can remarkably inhibit the growth of tumor in vivo. The above results suggested that compound 7m could be considered as a promising PI3Kα inhibitor.

Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1

We previously disclosed the discovery of rationally designed N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1 (GlyT-1), represented by analogues 10 and 11. We describe herein further structure-activit

five Yuan fragrance heterocyclic structure containing the anti-hepatitis c compound and its preparation and use

The invention discloses an anti-HCV (hepatitis C) compound containing a five-membered heteroaromatic ring structure, as well as a preparation method and applications thereof. The compound has a structure shown as the formula I, the compound has excellent anti-HCV virus activity, can be used for preparing anti-HCV drugs, the prepared drugs can be applied by adopting oral administration, intravenous injection or intramuscular injection.

Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl) cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1

The design, synthesis, and structure-activity relationships (SAR) of a series of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1 (GlyT-1) are described. Optimization of the benzamide and central ring

NOVEL COMPOUNDS - 644

The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6 and L are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are useful in the treatment of hepatitis C virus.

2,5-Disubstituted pyridines as potent GPR119 agonists

A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor.

HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C

Use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or alleviating HCV, formula (I): wherein R1, R2, R4, Y1, Y2, Y3, A, B and W are as defined in the specification.