505097-10-9Relevant academic research and scientific papers
Regioselective aluminium chloride induced heteroarylation of pyrrolo[1,2-b]pyridazines: Its scope and application
Pal, Manojit,Batchu, Venkateswara Rao,Khanna, Smriti,Yeleswarapu, Koteswar Rao
, p. 9933 - 9940 (2002)
We describe a detailed study on the novel synthesis of 6,7-disubstituted pyrrolo[1,2-b]pyridazines through AlCl3 induced C-C bond formation reactions. A wide variety of 6-aryl substituted azolopyridazines was reacted with 3,6-dichloropyridazine to give 7-pyridazinyl substituted pyrrolopyridazines regioselectively in good to excellent yield. The mechanism and regiochemistry of the reaction along with applications of the methodology are discussed.
