1632-74-2

Usage

Uses

Used in Pharmaceutical Research:
3,6-Dimethyl Pyridazine is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the development of new drugs. Its unique structure and reactivity allow for the creation of a wide range of medicinal agents.
Used in Agrochemical Development:
In the agrochemical industry, 3,6-Dimethyl Pyridazine is utilized as a precursor in the production of various agrochemicals, contributing to the development of effective and innovative products for agricultural applications.
Used in Organic Synthesis:
3,6-Dimethyl Pyridazine serves as a valuable building block in organic synthesis, enabling the creation of a diverse array of chemical compounds for various applications across different industries.
Used in Chemical Production:
As an intermediate, 3,6-Dimethyl Pyridazine is instrumental in the production of other chemicals and materials, highlighting its importance in the broader chemical manufacturing sector.

Upstream product

• 68206-05-3 4-chloro-3,6-dimethylpyridazine 
• 18091-25-3 2,5-dimethoxy-2,5-dimethyl-2,5-dihydro-furan 
• 57542-36-6 3,6-dimethyl-2,3,4,5-tetrahydro-pyridazine-3-carbonitrile 
• 61892-85-1 3-hydroxyhexane-2,5-dione 
• 110-13-4 2,5-hexanedione 
• 7647-01-0 hydrogenchloride 
• 55643-61-3 3,6-dimethyl-pyridazine-4,5-dicarboxylic acid 
• 17417-53-7 3,6-dimethyl-1H-pyridazin-4-one 
• 40838-54-8 3,6-Bis-(chlormethyl)-4-oxo-1,4-dihydropyridazin 
• 17417-44-6 NSC 166900 
• 3031-66-1 3-hexyn-2,5-diol 
• 5910-89-4 2,3-dimethylpyrazine 
• 14331-54-5 2,4-dimethylpyrimidine 
• 625-86-5 2,5-dimethylfuran 

Downstream Products

• 139242-96-9 2,4,6-Trimethyl-benzenesulfonate1-amino-3,6-dimethyl-pyridazin-1-ium; 
• 505097-16-5 6-(4-ethylphenyl)-2-methylpyrrolo[1,2-b]pyridazine 
• 505097-10-9 6-(4-methylphenyl)-2-methylpyrrolo[1,2-b]pyridazine 
• 78213-68-0 3,6-diformylpyridazine 
• 139243-16-6 2,4,6-Trimethyl-benzenesulfonate9-methyl-7,8-diaza-7a-azonia-benzo[k]fluoranthene; 
• 139243-36-0 2,4,6-Trimethyl-benzenesulfonate11-methyl-9,10-diaza-9a-azonia-benzo[b]triphenylene; 
• 1210518-75-4 dimethyl 2-((4-(5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl)phenyl)ethynyl)-2',4a'-dimethyl-4a'H-spiro[fluorene-9,5'-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate 
• 1210518-79-8 dimethyl 2,7-bis((4-(5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl)phenyl)ethynyl)-2',4a'-dimethyl-4a'H-spiro[fluorene-9,5'-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate 
• 1210518-76-5 dimethyl 2-((4-(5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl)phenyl)buta-1,3-diynyl)-2',4a'-dimethyl-4a'H-spiro[fluorene-9,5'-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate 
• 1210518-81-2 dimethyl 2,7-bis((4-(5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl)phenyl)buta-1,3-diynyl)-2',4a'-dimethyl-4a'H-spiro[fluorene-9,5'-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate 
• 27914-99-4 3,6-dimethylpyridazine 1-oxide 
• 19194-90-2 3,6-dimethylpyridazine-N,N-dioxide 
• 1417826-25-5 C₁₈H₁₅F₃N₂O₂ 
• 57266-70-3 pyridazine-3,6-dicarboxylic acid 

Relevant academic research and scientific papers

BIS-BENZIMIDAZOLE COMPOUNDS AND METHODS OF USING SAME

Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1 ), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.

Compounds for treating spinal muscular atrophy

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

Vapor phase phototransposition chemistry of dimethylpyrazines and dimethylpyrimidines

Based on their phototransposition chemistry, the three dimethylpyrazines and four dimethylpyrimidines can be arranged into two groups. 2,5-Dimethylpyrazine, 2,5-dimethylpyrimidine, and 4,6-dimethylpyrimidine constitute a photochemical triad. Irradiation of any one member of the triad in the vapor phase results in the formation of the other two members. The other four isomers, 2,6-dimethylpyrazine, 2,3-dimethylpyrazine, 2,4- dimethylpyrimidine, and 4,5-dimethylpyrimidine constitute a photochemical tetrad. Irradiation of any one member results in the formation of the other three. In addition, 2,4-dimethylpyrimidine and 2,6-dimethylpyrazine also photoisomerize to 3,6-dimethylpyridazine. Irradiation of the last in the vapor state resulted in the four members of the tetrad.

Synthesis of furans, pyrroles and pyridazines by a ruthenium-catalysed isomerisation of alkynediols and in situ cyclisation

Alkyne-1,4-diols are readily available substrates which are isomerised to 1,4-diketones using Ru(PPh3)3(CO)H2/xantphos as a catalyst. In situ cyclisation into furans, pyrroles and pyridazines has been achieved under suitable conditions.

Synthesis and structure of dilead(II) and dimanganese(II) complexes of macrocycles derived from 3,6-diformylpyridazine

An improved synthesis of 3,6-diformylpyridazine I has been elaborated. The macrocyclic complexes Pb2L1(ClO4)4 1 and [Pb2L2][ClO4]4 2 were prepared from this precursor, 1,3-diaminopropane and lead(II) perchlorate in 1:1:1 and 2:2:1 ratios respectively. The ability of lead(II) perchlorate to template the formation of the two macrocycle ring sizes, L1 = (2 + 2) and L2 = (4 + 4), simply by alteration of the reagent ratio is unprecedented. Transmetallation of 1 or 2 with manganese(II) perchlorate and an excess of sodium thiocyanate led to the formation of [Mn2L1(NCS)4] 3. Single-crystal X-ray analyses of 2 and 3 revealed that on transmetallation a ring contraction, (4 + 4) to (2 + 2), occurs. The two manganese(II) ions have irregular geometries and are inequivalent; one is six- whilst the other is seven-co-ordinate. Unusual single-atom > NCS bridging of the manganese ions occurs.

Fungicidal pyridazines

Plants are protected from the damaging effects of Phycomycetous fungi by a series of pyridazines of formula STR1 wherein R3 is chloro, bromo, methyl, cyano or iodo; R is chloro, bromo, iodo, methyl, cyano or furan-2-ylmethoxy; R1 is