50523-18-7

Upstream product

• 3577-87-5 diphenyl methyl phosphite 
• 598-31-2 1-bromoacetone 
• 101-02-0 triphenyl phosphite 
• 78-95-5 chloroacetone 

Downstream Products

• 112057-17-7 2-(N-Benzyl-N-methylamino)-ethyl 2,6-dimethyl-4-(3-nitrophenyl)-5-diphenoxyphosphinyl-1,4-dihydropyridine-3-carboxylate 

Relevant academic research and scientific papers

One-pot synthesis of optically active β-amino-α-methylene carbonyl derivatives from α-amidosulfones using quinine-based phase-transfer catalysts

Optically active β-amino-α-methylene carbonyl derivatives (aza-Morita-Baylis-Hillman adducts) were prepared using a one-pot protocol involving an enantioselective Mannich reaction catalyzed by various quinine-based catalysts, followed by a Horner olefination.

Alkyl phosphonate preparing method

The invention provides an alkyl phosphonate preparing method. The method comprises: performing an Arbuzov reaction on compound A and compound B in a continuous reaction apparatus, and continuously discharging the product obtained from the reaction from the continuous reaction apparatus during the reaction procedure, to obtain alkyl phosphonate. The reaction temperature in the reaction procedure is T1; either of compound A and compound B having a lower boiling point has a boiling point at a standard atmosphere pressure to be T2; T1 is higher than T2 by 10-40 DEG C; and the reaction pressure in the reaction procedure is 0.5-2.0 MPa. The preparing method in the invention may use halohydrocarbon having large steric hindrance and lower polarizability of carbon-halogen bond as compound A, thereby effectively expanding a selection range of substrate, and correspondingly expanding the types of alkyl phosphonate prepared by using the Arbuzov reaction.