50528-53-5

Usage

Uses

Used in the Production of Polyurethane Foams:
2,6-DIMETHOXYPHENYL ISOCYANATE is used as a key chemical intermediate for the production of polyurethane foams, which are known for their versatility, durability, and insulation properties. It contributes to the creation of flexible and rigid foams used in furniture, bedding, insulation materials, and more.
Used in the Manufacturing of Coatings:
In the coatings industry, 2,6-DIMETHOXYPHENYL ISOCYANATE is used as a reactive component in the formulation of various types of coatings. These coatings provide protection, durability, and aesthetic appeal to a wide range of surfaces, including automotive, architectural, and industrial applications.
Used in the Formulation of Adhesives:
2,6-DIMETHOXYPHENYL ISOCYANATE is used as a critical ingredient in the development of adhesives, which are essential for bonding various materials together. Its high reactivity ensures strong adhesion and durability in applications such as construction, automotive, and packaging industries.
Used in the Creation of Sealants:
In the sealants industry, 2,6-DIMETHOXYPHENYL ISOCYANATE is used as a vital component in the production of sealants that provide airtight and waterproof barriers. These sealants are crucial in construction, automotive, and aerospace applications to ensure the integrity and longevity of the structures and components.

InChI:InChI=1/C9H9NO3/c1-12-7-4-3-5-8(13-2)9(7)10-6-11/h3-5H,1-2H3

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 2734-70-5 2,6-dimethoxyaniline 

Downstream Products

• 1338792-12-3 3-(5-(3-(2,6-dimethoxyphenyl)ureido)-1H-indazol-3-yl)benzenesulfonamide 

Relevant academic research and scientific papers

Concentration-Dependent Thermal Isomerization of Nitrile N-Oxide

Kinetically stabilized nitrile N-oxides (NOs) have been regarded as viable tools for the postpolymerization functionalization of common polymers. However, thermal isomerization of NO to isocyanate restricts the applications of NO to industrial use. The re

Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivatives

Based on the structural modification of molecular-targeted agent sorafenib, a series of quinazolinyl-arylurea derivatives were synthesized and evaluated for their anti-proliferative activities against six human cancer cell lines. Compared with other cell lines tested, T24 was more sensitive to most compounds. Compound 7j exhibited the best profile with lower IC50 value and favorable selectivity. In this study, we focused on 7j-induced death forms of T24 cells and tried to elucidate the reason for its potent proliferative inhibitory activity. Compound 7j treatment could trigger three different cell death forms including apoptosis, ferroptosis, and autophagy; which form would occur depended on the concentrations and incubation time of 7j: (1) Lower concentrations within the initial 8 h of 7j treatment led to apoptosis-dependent death. (2) Ferroptosis and autophagy occurred in the case of higher concentrations combining with extended incubation time through effectively regulating the Sxc?/GPx4/ROS and PI3K/Akt/mTOR/ULK1 pathways, respectively. (3) The above death forms were closely associated with intracellular ROS generation and decreased mitochondrial membrane potential induced by 7j. In molecular docking and structure-activity relationship analyses, 7j could bind well to the active site of the corresponding receptor glutathione peroxidase 4 (GPx4). Compound 7j could be a promising lead for molecular-targeted anti-bladder cancer agents’ discovery.

Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton.

Potent, specific, chemically stable and non-peptide/small-molecular inhibitors of puromycin-sensitive aminopeptidase, such as 3-(2,6-diethylphenyl)-2,4(1H,3H)-quinazolinedione (PAQ-22, 5), were prepared by the structural development of a potent PSA inhibitor, 2-(2,6-diethylphenyl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (PIQ-22, 4). The design was carried out partly by applying electrostatic potential field information obtained from PIQ-22 (4) and its derivatives based on thalidomide (2). This information revealed that a positive electrostatic potential field around the benzylic methylene in the tetrahydroisoquinoline ring is necessary for potent activity. Lineweaver-Burk plot analysis showed that PAQ-22 (5) and its derivatives inhibit puromycin-sensitive aminopeptidase (PSA) in a non-competitive manner. These potent and specific PSA inhibitors showed dose-dependent cell invasion-inhibitory activity in a Matrigel assay using mouse melanoma B16F10/L5 cells, in spite of their low cell toxicity.