50534-33-3

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[1-(phenylmethyl)-4-piperidinyl]-
• CAS NO: 50534-33-3
• Molecular Formula: C20H20N2O2
• Molecular Weight: 320.391
• Mol File: 50534-33-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[1-(phenylmethyl)-4-piperidinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[1-(phenylmethyl)-4-piperidinyl]-(50534-33-3)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[1-(phenylmethyl)-4-piperidinyl]-(50534-33-3)

Safety Data

• Hazardous Substances Data: 50534-33-3(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 50541-93-0 4-amino-1-benzylpiperidine 
• 136918-14-4 phthalimide 
• 4727-72-4 1-benzyl-4-hydroxypiperidine 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 22509-74-6 N-ethoxycarbonylphthalimide 

Downstream Products

• 50541-93-0 4-amino-1-benzylpiperidine 
• 280141-23-3 C₂₁H₂₄N₂O₂ 
• 321733-39-5 1-[4-(5,5-dimethyl-1,3-dioxan-2-yl)phenyl]-4-phthalimidopiperidine 
• 321733-40-8 1-(4-formylphenyl)-4-phthalimidopiperidine 

Relevant articles and documents

Synthesis of novel N-benzyl substituted piperidine amides of 1H-indole-5-carboxylic acid as potential inhibitors of cholinesterases

A series of novel N-benzyl substituted amides of 1H-indole-5-carboxylic acid were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The target compounds (6b-6e) displayed moderate potency to inhibit BuChE. One of the compounds tested, i.e., 1-benzylpiperidine amide of 1H-indole-5-carboxylic acid (6a) was a weak, non-selective inhibitor for both enzymes. The highest inhibitory activity towards BuChE (30.06% [10 μM]) was determined for compound (6c) which is 1-(3-chloro)benzylpiperidine amide of 1H-indole-5-carboxylic acid.

Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors

Truncation of potent and selective dibasic inhibitors afforded monocharged inhibitors of human mast-cell tryptase. Using two classes of analogues as lead structures, several monocharged derivatives were identified with Ki values ranging from 0.

Inhibitors of microsomal triglyceride transfer protein and method

Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure STR1 wherein R1 to R7, Q, X and Y are as defined herein.