50534-45-7

Usage

Uses

Used in Pharmaceutical Industry:
1-ETHYL-PIPERIDIN-4-YLAMINE is used as a building block for the synthesis of various pharmaceuticals, leveraging its unique structure and reactivity to contribute to the development of new medicinal compounds.
Used in Agrochemical Industry:
1-ETHYL-PIPERIDIN-4-YLAMINE is utilized as a key component in the creation of agrochemicals, playing a significant role in the formulation of products designed to protect and enhance crop yields.
Used in Fine Chemicals Production:
1-ETHYL-PIPERIDIN-4-YLAMINE is employed as an intermediate in the production of fine chemicals, where its specific chemical properties are harnessed to produce high-quality specialty chemicals.
Used in Surfactant Manufacturing:
As an intermediate, 1-ETHYL-PIPERIDIN-4-YLAMINE is used in the manufacturing of surfactants, which are essential in a variety of applications, including detergents, wetting agents, and emulsifiers.
Used in Antioxidant Production:
This chemical serves as an intermediate in the production of antioxidants, which are crucial in various industrial applications to prevent oxidative degradation and extend the shelf life of products.
Used in Dye Manufacturing:
1-ETHYL-PIPERIDIN-4-YLAMINE is also used in the synthesis of dyes, contributing to the coloration and enhancement of textiles, plastics, and other materials in the dye industry.

InChI:InChI=1/C7H16N2/c1-2-9-5-3-7(8)4-6-9/h7H,2-6,8H2,1H3

Upstream product

• 99329-51-8 ethyl 1-ethyl-4-oxopiperidine-3-carboxylate 
• 182223-54-7 piperidin-4-ylcarbamic acid benzyl ester 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 220394-97-8 4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine 
• 3612-18-8 N-ethyl-4-piperidone 

Downstream Products

• 102535-19-3 N-(1-Ethyl-piperidin-4-yl)-2-methoxy-5-sulfamoyl-benzamide 
• 84332-23-0 2-Amino-4-methoxy-pyrimidine-5-carboxylic acid (1-ethyl-piperidin-4-yl)-amide 
• 1229021-65-1 C₂₄H₂₅N₅O 
• 1179265-01-0 4-amino-N-(1-ethyl-piperidin-4-yl)-benzamide 
• 1201693-09-5 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-2,3-difluoro-benzamide 
• 1201692-99-0 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-2,5-difluoro-benzamide 
• 1201692-81-0 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-ethoxy-N-(1-ethyl-piperidin-4-yl)-benzamide 
• 1201692-73-0 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-3-trifluoromethyl-benzamide 
• 1201692-65-0 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-3-ethyl-N-(1-ethyl-piperidin-4-yl)-benzamide 
• 1201692-57-0 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-3-methyl-benzamide 
• 1201692-89-8 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-3-fluoro-benzamide 
• 1001346-95-7 4-amino-N-(1-ethyl-piperidin-4-yl)-3-methoxy-benzamide 
• 1201692-55-8 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxy-N-(1-ethyl-piperidin-4-yl)-benzamide 
• 1137867-41-4 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-ethyl-piperidin-4-yl)-3-methoxy-benzamide 

Relevant academic research and scientific papers

Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in?vivo anti-tumor activity

Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1?cells (PF50?=?7.10, PF50?=?4.17). In?vivo tumor growth inhibition was investigated using compound 10a in combination with TMZ, and it was demonstrated that compound 10a could strongly potentiate the cytotoxicity of TMZ in MX-1 xenograft tumor model. Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.

2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY

A compound of formula (I′) or (I′′) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity.

TROPANE COMPOUNDS

A compound according to Formula I or II: (I) or (II) wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.

NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation

ALKYLCARBAMOYL NAPHTHALENYLOXY- OCTENOYLHYDROXYAMIDE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PREPARATION THEREOF

This invention discloses a novel alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide derivative of formula (1) useful for inhibiting the enzyme activity of histone deacetylase, which leads to effective suppression of the cancer cell proliferation, a method for preparing same and a pharmaceutical composition comprising same.