50545-37-4

Upstream product

• 2450-26-2 2-nitrovanillin 
• 621-59-0 isovanillin 
• 121-33-5 vanillin 
• 881-68-5 vanillin acetate 
• 2698-69-3 4-formyl-2-methoxy-3-nitrophenyl acetate 
• 6284-92-0 3-hydroxy-4-methoxy-2-nitrobenzaldehyde 

Downstream Products

• 1103519-66-9 C₁₇H₁₅NO₆ 
• 132277-42-0 7-[1,3]Dioxolan-2-yl-2,2-dimethyl-6-nitro-3-phenylselanyl-3,4-dihydro-2H-benzo[b][1,4]dioxepine 
• 132277-40-8 2,2-Dimethyl-6-nitro-3-phenylselanyl-3,4-dihydro-2H-benzo[b][1,4]dioxepine-7-carbaldehyde 
• 132302-22-8 2-(3,3-Dimethyl-oxiranylmethoxy)-4-[1,3]dioxolan-2-yl-3-nitro-phenol 
• 50545-38-5 3,4-Di(benzyloxy)-2-nitrobenzaldehyd 
• 132277-38-4 4-[1,3]Dioxolan-2-yl-3-nitro-benzene-1,2-diol 

Relevant academic research and scientific papers

Class of large ring heterocyclic compound restraining HCV and manufacturing and uses thereof

The invention relates to a class of compounds that inhibit HCV. The compounds are represented by Formula A. The invention also relates to preparation and pharmaceutical use of the compounds.

Synthesis and antitumor activity of feruloyl and caffeoyl derivatives This paper is dedicated to Prof. Wei-xiao Hu for his lifelong commitment to mentoring graduate students

We developed two efficient protocols for the synthesis of feruloyl and caffeoyl derivatives from commercial vanillin and veratraldehyde. Pharmacological activities were assessed against a panel of human cancer cell lines in vitro. Most synthesized compounds demonstrated attractive cytotoxicity. Several new compounds demonstrated significant antiproliferative and cytotoxic activities against HeLa and Bewo tumor cell lines. In particular, 5-nitro caffeic adamantyl ester showed broad spectrum of tumor inhibition in 10 cell lines, and reduced tumor weight by 36.7% in vivo when administered at a dose of 40 mg kg-1.

Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines

Forty caffeate analogues were synthesized via a convenient method starting from vanillin with moderate to good yields. The testing of biological activity of these compounds against HIV-1 integrase indicates that four compounds: bornyl caffeate, bornyl 2-nitrocaffeate, 5-nitrocaffeic acid and 5-nitrocaffeic acid phenethyl ester (5-nitroCAPE) possess a good HIV integrase inhibitory activity, IC50 19.9, 26.8, 25.0 and 13.5 μM, respectively. Twelve caffeate analogues were tested by MTT assay on growth of human hepatocellular carcinoma BEL-7404, human breast MCF-7 adenocarcinoma, human lung A549 adenocarcinoma and human gastric cancer BCG823 cell lines, respectively. And the best result is IC50 5.5 μM for CAPE against BEL-7404.

SYNTHETIC STUDIES ON PARAHERQUAMIDE: SYNTHESIS OF THE 2H-1,5-BENZODIOXEPIN RING SYSTEM

Various 2H-2,2-dimethyl-1,5-benzodioxepins have been synthesized en route to the oxindole moiety of paraherquamide (1).The key step is the 7-membered ring formation from prenylated catechols using either PhSeCl, N-PSP or m-CPBA/SnCl4.