50586-97-5Relevant academic research and scientific papers
Further studies on the structure activity relationships in the C terminal part of luteinizing hormone releasing hormone
Fujino,Shinagawa,Obayashi,Kobayashi,Fukuda
, p. 1144 - 1147 (1973)
Nine new analogs of luteinizing hormone releasing hormone (LH RH), i.e. [Des Gly NH210,Pro n butylamide9] LH RH, [Des Gly NH 210,Pro OMe9] LH RH, [Des Gly NH210,Pro OEt9] LH RH, [Des Gly NH210,Pro dimethylamide9] LH RH, [Des Gly NH210,Pro piperidineamide9] LH RH, [Pro10] LH RH, [Des Gly NH210,Pro isopropylamide9] LH RH, [Des Gly NH210,Pro isobutylamide9] LH RH, and [Des Gly NH210,Pro cyclohexylamide9] LH RH, were synthesized by the solution method and some biological properties of these analogs were measured. On the basis of the LH and FSH releasing activities and the ovulation inducing activities of these analogs and the previously reported nonapeptide alkylamide analogs, structure activity relations in the C terminal part of this releasing hormone are discussed in detail.
