Further studies on the structure activity relationships in the C terminal part of luteinizing hormone releasing hormone

Article abstract of DOI:10.1021/jm00268a017

Nine new analogs of luteinizing hormone releasing hormone (LH RH), i.e. [Des Gly NH₂¹⁰,Pro n butylamide⁹] LH RH, [Des Gly NH ₂¹⁰,Pro OMe⁹] LH RH, [Des Gly NH₂¹⁰,Pro OEt⁹] LH RH, [Des Gly NH₂¹⁰,Pro dimethylamide⁹] LH RH, [Des Gly NH₂¹⁰,Pro piperidineamide⁹] LH RH, [Pro¹⁰] LH RH, [Des Gly NH₂¹⁰,Pro isopropylamide⁹] LH RH, [Des Gly NH₂¹⁰,Pro isobutylamide⁹] LH RH, and [Des Gly NH₂¹⁰,Pro cyclohexylamide⁹] LH RH, were synthesized by the solution method and some biological properties of these analogs were measured. On the basis of the LH and FSH releasing activities and the ovulation inducing activities of these analogs and the previously reported nonapeptide alkylamide analogs, structure activity relations in the C terminal part of this releasing hormone are discussed in detail.