50593-24-3 Usage
Description
1-METHYL-1H-INDAZOL-5-AMINE is an organic compound with the molecular formula C8H8N2. It is a heterocyclic compound, specifically an indazole derivative, which is known for its potential applications in the pharmaceutical and chemical industries due to its unique chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
1-METHYL-1H-INDAZOL-5-AMINE is used as a key intermediate compound in the synthesis of Hydrazone compounds with a (hetero)aryl group at the terminal amine group. These Hydrazone compounds are utilized for treating tau protein-associated diseases, which are a group of neurodegenerative disorders characterized by the abnormal accumulation of tau protein in the brain.
1-METHYL-1H-INDAZOL-5-AMINE is also used in the preparation of Dihydroisoindole-1H-pyrazolo[3,4-d]pyrimidinone compounds, which serve as Wee1 inhibitors. Wee1 is a protein kinase that plays a crucial role in regulating the cell cycle, and its inhibition has been shown to have potential therapeutic benefits in the treatment of kinase-related diseases, which are a class of disorders caused by the abnormal activity of protein kinases.
Check Digit Verification of cas no
The CAS Registry Mumber 50593-24-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,5,9 and 3 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 50593-24:
(7*5)+(6*0)+(5*5)+(4*9)+(3*3)+(2*2)+(1*4)=113
113 % 10 = 3
So 50593-24-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H9N3/c1-11-8-3-2-7(9)4-6(8)5-10-11/h2-5H,9H2,1H3
50593-24-3Relevant articles and documents
SnCl2/EtOH-mediated Synthesis of Novel 4-Ethoxy-and 4-Chloroindazoles Bearing Sulfonamide Moieties
Chicha, Hakima,Bouissane, Latifa,El Ammari, Lahcen,Saadi, Mohamed,Baltas, Michel,El Mostapha, Rakib
, p. 2005 - 2013 (2015)
The treatment of N-alkyl-5-nitroindazole with stannous chloride in ethanol, aftercoupling of the obtained amines with arylsulfonyl chloride in pyridine, gave the new 4-ethoxy-and 4-chloroindazoles bearing sulfonamide in moderate to good yields. Chlorinati
An Alternative Indazole Synthesis for Merestinib
Lu, Yu,Cole, Kevin P.,Fennell, Jared W.,Maloney, Todd D.,Mitchell, David,Subbiah, Ramesh,Ramadas, Balakumar
, p. 409 - 419 (2018/03/22)
A new synthesis of a key indazole-containing building block for the MET kinase inhibitor merestinib was designed and demonstrated. Crucial to the successful construction of the challenging indazole is an SNAr reaction, which forges the heterocy
THIENO[3,2-D]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES
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Paragraph 0662; 0663; 0664, (2015/01/06)
Provided are a thieno[3,2-d]pyrimidine derivative of formula (I) or a pharmaceutically acceptable salt thereof having inhibitory activity for protein kinase, and a pharmaceutical composition comprising same for prevention and treatment of abnormal cell growth diseases.
