50593-68-5

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C7H4ClN3O2/c8-7-5-2-1-4(11(12)13)3-6(5)9-10-7/h1-3H,(H,9,10)

Upstream product

• 7364-33-2 6-nitro-1,2-dihydro-3H-indazol-3-one 
• 7597-18-4 6-nitroindazole 
• 5401-94-5 5-nitroindazole 
• 3481-09-2 N-chlorophthalimide 
• 74209-31-7 3-chloro-1-methyl-6-nitro-1H-indazole 

Downstream Products

• 119872-45-6 7-Benzenesulfonylmethyl-3-chloro-6-nitro-1H-indazole 
• 68159-09-1 1-acetyl-3-chloro-6-nitroindazole 
• 119872-52-5 1-(7-Benzenesulfonylmethyl-3-chloro-6-nitro-indazol-1-yl)-ethanone 
• 854923-20-9 3-chloro-6-nitro-1-(2-pyrrolidin-1-yl-ethyl)-1H-indazole 
• 74209-40-8 3-chloro-2-methyl-6-nitro-2H-indazole 
• 74209-31-7 3-chloro-1-methyl-6-nitro-1H-indazole 
• 219507-79-6 1-Boc-3-chloro-6-nitroindazole 
• 49820-95-3 2-(3-chloro-1⁽²⁾H-indazol-6-ylamino)-benzoic acid 
• 21413-23-0 3-chloro-6-amino-1H-indazole 

Relevant academic research and scientific papers

BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS

The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.

Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor

The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor

The present invention relates to the antagonism of the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders.

Lactam inhibitors of factor Xa and method

Lactam inhibitors are provided which have the structure including pharmaceutically acceptable salts thereof and all stereoisomers thereof, and prodrug esters thereof, wherein n is 1 to 5; and and R1, R2, R3, R4, R5 , R6, R7, R8, R9, R10, R10a, 1011 and R12 are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants. A method for treating cardiovascular diseases associated with thromboses is also provided.

SYNTHESIS OF SUBSTITUTED PYRAZOLO- AND PYRAZOLOPHENOTHIAZINE DERIVATIVES

The synthesis of new pyrazolo- and phenothiazines by the Bernthsen thionation of N-arylindazoles obtained using organometalic compounds is reported.

Synthesis of Pyrazoloacridin-9(10H)-ones

Eight pyrazoloacridin-9(10H)-ones were prepared in a three step procedure from 5- and 6-nitroindazoles.Palladium catalysed hydrogenation of nitroindazoles afforded the corresponding 5- and 6-aminoindazoles.These, in turn, reacted with o-chlorobenzoic acid under the conditions of the Ullman reaction to give anthranilic acids.Cyclisation of these acids by means of sulfuric acid led to the title compounds.If phosphoryl chloride was used, instead of sulfuric acid, a 9-chloroacridine derivative was obtained.All the compounds were characterised by 1H NMR spectroscopy.

PHOTOCHIMIE D'HETEROCYCLES AZOTES-VI. SYNTHESE PAR VOIE PHOTOCHIMIQUE D'AMINO ET D'ALKOXY INDAZOLES

The preparation of different aminoindazoles by nucleophilic aromatic photosubstitution of nitroindazoles by amines is described.In this manner, the amino, methylamino, dimethylamino and diethylamino substituents are introduced in 3, 4, 5 or 7-position.The irradiation in the presence of ethanol gives ethoxyindazoles in only four cases.Two demethylation reactions have been observed: the first one concerns the formation of methylamino derivatives starting from dimethylamine; the second one, the formation of N(H)1-indazoles by irradiation in presence of diethylamine.