7364-33-2

Usage

Uses

Used in Pharmaceutical Industry:
3-Hydroxy-6-nitro (1H) indazole is used as a key intermediate in the synthesis of various pharmaceuticals for its anti-tumor and anti-inflammatory properties. It plays a crucial role in the development of new drugs targeting cancer and inflammatory conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Hydroxy-6-nitro (1H) indazole is utilized as a precursor in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in Medicinal Chemistry Research:
3-Hydroxy-6-nitro (1H) indazole is employed as a research compound in medicinal chemistry, where it is studied for its potential therapeutic applications in the treatment of neurological disorders. Its cytotoxic properties also make it a valuable tool in the discovery of new drugs targeting various diseases.
Used in Organic Synthesis:
3-Hydroxy-6-nitro (1H) indazole serves as a versatile building block in organic synthesis, enabling the creation of a wide range of fine chemicals and specialty compounds for various applications across different industries.

InChI:InChI=1/C7H5N3O3/c11-7-5-2-1-4(10(12)13)3-6(5)8-9-7/h1-3H,(H2,8,9,11)

Upstream product

• 392-09-6 2-fluoro-4-nitro-benzoic acid methyl ester 
• 619-17-0 4-Nitroanthranilic acid 
• 618445-83-3 3,3-dimethyl-1-piperidin-4-ylmethyl-2,3-dihydro-1H-indol-6-ylamine 
• 453562-51-1 {2-[4-(tert-butyl)-2-amino-phenoxy]-ethyl}-dimethylamine 
• 453562-53-3 1-[2-(tert-butyl)-5-aminophenyl]-4-methylpiperazine 

Downstream Products

• 59673-74-4 6-amino-1,2-dihydro-3H-indazole-3-one 
• 50593-68-5 3-chloro-6-nitro-1H-indazole 
• 21413-23-0 3-chloro-6-amino-1H-indazole 
• 107753-57-1 methyl 4-[3-hydroxy-6-nitroindazol-1-ylmethyl]-3-methoxybenzoate 

Relevant academic research and scientific papers

Discovery of isatin and 1H-indazol-3-ol derivatives as D-amino acid oxidase (DAAO) inhibitors

D-Amino acid oxidase (DAAO) is a potential target in the treatment of schizophrenia as its inhibition increases brain D-serine level and thus contributes to NMDA receptor activation. Inhibitors of DAAO were sought testing [6+5] type heterocycles and identified isatin derivatives as micromolar DAAO inhibitors. A pharmacophore and structure-activity relationship analysis of isatins and reported DAAO inhibitors led us to investigate 1H-indazol-3-ol derivatives and nanomolar inhibitors were identified. The series was further characterized by pKa and isothermal titration calorimetry measurements. Representative compounds exhibited beneficial properties in in vitro metabolic stability and PAMPA assays. 6-fluoro-1H-indazol-3-ol (37) significantly increased plasma D-serine level in an in vivo study on mice. These results show that the 1H-indazol-3-ol series represents a novel class of DAAO inhibitors with the potential to develop drug candidates.

Substituted Oxopyridine Derivatives and Use Thereof in the Treatment of Cardiovascular Disorders

The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS

The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES

The invention relates to indazole derivatives of general formula (I) or (II), with the meanings as given in the description, the pharmaceutically-acceptable salts and use thereof as medicaments.

Indazole derivatives as inhibitors of hormone sensitive lipase

The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs.

INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS

The present invention provides compounds of formula (I): These compounds, and pharmaceutically acceptable compositions thereof, are useful generally as kinase inhibitors, particularly as inhibitors of PRAK, GSK3, ERK2, CDK2, MK2, SRC, SYK, and Aurora-2. Accordingly, compounds and compositions of the invention are useful for treating or lessening the severity of a variety of disorders, including, but not limited to, heart disease, diabetes, Alzheimer's disease, immunodeficiency disorders, inflammatory diseases, allergic diseases, autoimmune diseases, destructive bone disorders such as osteoporosis, proliferative disorders, infectious diseases and viral diseases.

Substituted amine derivatives and methods of use

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Substituted amine derivatives and methods of use

Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.