50593-74-3Relevant academic research and scientific papers
LiBr-promoted photoredox neutral Minisci hydroxyalkylations of quinolines with aldehydes
Ji, Xiaochen,Liu, Qiong,Wang, Zhongzhen,Wang, Pu,Deng, Guo-Jun,Huang, Huawen
, p. 8233 - 8237 (2020)
Photoredox-neutral hydroxyalkylations of quinolines with aldehydes, induced by sustainable visible light under mild conditions, are described. Non-toxic and inexpensive LiBr is found to be the key for the success of the atom-economical Minisci method. Combined with a highly oxidative photocatalyst and visible light irradiation, the bromide additive mediates the H abstraction/acyl radical formation directly from aldehydes. The present mild photoredox neutral protocol provides an important alternative, especially for the challenging Minisci hydroalkylations, as well as a promising approach for atom-economical Minisci reactions with broader N-heterocycle spectra.
