50606-33-2

Basic information

• Product Name: 1-Piperazinecarboxylic acid, phenyl ester
• Synonyms: piperazine-1-carboxylic acid phenyl ester;CBZ-piperazine;1-piperazinecarboxylic acid phenyl ester
• CAS NO: 50606-33-2
• Molecular Formula: C11H14N2O2
• Molecular Weight: 206.244
• Mol File: 50606-33-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxylic acid, phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, phenyl ester(50606-33-2)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, phenyl ester(50606-33-2)

Safety Data

• Hazardous Substances Data: 50606-33-2(Hazardous Substances Data)

Usage

Role in organic synthesis

Building block 1-Piperazinecarboxylic acid, phenyl ester is commonly used as a fundamental component in the synthesis of various pharmaceuticals and biologically active compounds.

Application in medicinal chemistry

Synthesis of pharmaceuticals This compound is used to create drugs for various medical conditions, particularly those related to central nervous system disorders.

Potential use in agrochemicals

Pest control and crop protection 1-Piperazinecarboxylic acid, phenyl ester can be utilized in the development of chemicals for agricultural purposes, such as controlling pests and protecting crops.

Upstream product

• 110-85-0 piperazine 
• 64897-42-3 phenyl 2,4-dinitrophenyl carbonate 
• 1885-14-9 phenyl chloroformate 
• 1170292-50-8 phenyl (2,4,6-trinitrophenyl) carbonate 
• 128337-08-6 phenyl-(2-pyridyl)carbonate 

Downstream Products

• 480991-46-6 C₃₁H₃₅N₅O₆ 
• 1391636-63-7 C₂₂H₂₅ClN₂O₄ 
• 1260098-95-0 4-(2-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-oxo-ethyl)-piperazine-1-carboxylic acid phenyl ester 
• 508233-74-7 vortioxetine 
• 960203-42-3 4-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester 
• 494773-35-2 4-(2-bromophenyl)piperazine-1-carboxylic acid tert-butyl ester 
• 1011-13-8 1-(2-bromophenyl)piperazine 
• 1392831-29-6 4-(imidazole-1-carbonyl)piperazine-1-carboxylic acid phenyl ester 
• 1392831-54-7 phenyl 4-(indoline-1-carbonyl)piperazine-1-carboxylate 
• 1392831-57-0 [4-(indoline-1-carbonyl)piperazin-1-yl](indolin-1-yl)methanone 
• 132019-64-8 4-[3-(5,11-Dihydro-10-thia-dibenzo[a,d]cyclohepten-5-ylcarbamoyl)-propyl]-piperazine-1-carboxylic acid phenyl ester 

Relevant articles and documents

A benzo [b] thiophene preparation method and intermediate

The invention provides a preparation method for benzo[b]thiophene. The preparation method comprises the following steps: substitution; ring closure; hydrolysis; decarboxylation; etc. The method effectively reduces generation of by-products, improves reaction yield, avoids usage of expensive reagents, decreases total cost and is applicable to industrial production. The invention further provides a novel compound. The novel compound is a key intermediate for preparation of benzo[b]thiophene and has a structure as shown in a formula 3 which is described in the specification. The invention also provides a preparation method for the compound 3, and the method has high yield and is simple to operate.

Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists

Optimization of a series of aminomethyl ketone diamine H3R antagonists to reduce the brain exposure by lowering the pKa, led to molecules with improved pharmacokinetic properties. Compounds 9, 19, and 25 had high affinity for human H3R and demonstrated in vivo H3R functional activity in the rat dipsogenia model. Compound 9 displayed modest wake-promoting activity in the rat EEG/EMG model.

Concerted aminolysis of diaryl carbonates: Kinetic sensitivity on the basicity of the nucleophile, nonleaving group, and nucleofuge

The kinetics of the reactions of 4-methylphenyl, phenyl, and 4-chlorophenyl 2,4,6-trinitrophenyl carbonates (1, 2, and 3, respectively) with a series of anilines and secondary alicyclic (SA) amines has been carried out spectrophotometrically in 44 wt% ethanol-water, at 25.0°C, ionic strength 0.2 M. The BrAnsted plots (statistically corrected) for the reactions of carbonates 1-3 with anilines and SA amines were linear with slopes (βN) in the range of 0.69-0.78 and 0.45-0.48, respectively, attributed to a concerted mechanism. The negative values found for the sensitivity of log kN to the basicity of the nonleaving (βnlg) and leaving (βlg) groups are discussed. Anilines are more reactive than isobasic SA amines, probably because of the greater steric hindrance offered by the latter.