50609-80-8

Upstream product

• 3282-32-4 2-diazo-acetophenone 
• 50609-85-3 (E)-3-methylamino-3-methylthio-1-phenylprop-2-ene-1-thione 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 

Relevant academic research and scientific papers

Rhodium(II)-mediated reactions of thiobenzoylketene S,N-acetals with α-diazo carbonyl compounds: Synthesis of 2-substituted 3-alkylamino-5-phenylthiophenes

Treatment of 3-methylamino-3-methylsulfanyl-1-phenylpropenethione 1 with excess (2.5 equiv.) α-diazo carbonyl compounds such as α-diazoketones and α-diazoesters in the presence of a catalytic amount of Rh(II) acetate in CH2Cl2 at rt gave 2-acyl- or 2-aroyl-3-methylamino-5-phenylthiophenes and alkyl 3-methylamino-5-phenylthiophene-2-carboxylates, respectively, as major products along with 1-phenyl-2-methylsulfanylethanones. The formation of the major products indicates that the carbenes or carbenoids generated interact initially with the thione sulfur of 1.

Novel synthesis of 3-alkyl-2,5-diaryl-1,4-oxathiepin-7-ones

N-Acetyl-N-methyl-3-aryl-3-[1-(aroyl)ethylthio]-2-propaneamides, prepared from thioaroylketene S,N-acetals, Hg(OAc)2 and silyl enol ethers of aryl-1-propanones in CH2Cl2 at rt, reacted with NaH in THF to give the title compounds in excellent yields.