50609-85-3

Upstream product

• 18712-05-5 2-methyl-3-methylthio-5-phenylisothiazolium iodide 
• 100-46-9 benzylamine 
• 91787-80-3 3-methylamino-3-methylthio-1-phenylprop-2-en-1-one 
• 13636-88-9 3,3-bis(methylthio)-1-phenylprop-2-en-1-one 
• 30162-68-6 2-methyl-5-phenyl-4-isothiazolin-3-thione 
• 4849-59-6 5-phenyl-3-methylthio-1,2-dithiolium iodide 

Downstream Products

• 85311-75-7 3-Methyl-6-phenyl-2-[(E)-phenylimino]-2,3-dihydro-[1,3]thiazin-4-one 
• 92802-07-8 ethyl 3-(methylamino)-5-phenylthiophene-2-carboxylate 
• 213180-70-2 2-ethoxycarbonyl-2-methanesulfonyl-3-methylamino-5-phenyl-2,3-dihydrothiophene 
• 50609-80-8 2-benzoyl-3-methylamino-5-phenylthiophene 
• 478028-07-8 methyl 3-(methylamino)-5-phenylthiophene-2-carboxylate 
• 213180-58-6 1-(3-Methylamino-5-phenyl-thiophen-2-yl)-ethanone 
• 282110-99-0 ethyl 2-(3-methylamino-5-phenyl-2-thenoyl)phenyloxoacetate 
• 282110-89-8 N-methyl-5-phenylthiophen-3-amine 

Relevant academic research and scientific papers

Facile synthesis of 4-alkyl (and aryl)-2-aryl-6-diazo-4H-thieno[3,2-b] pyridine-5,7-diones

Treatment of 3-{3-alkyl (and aryl)amino-5-arylthieno-2-yl}-2-diazo-3- oxopropanoates 8 with TMSOTf (3 equiv) in the presence of Et3N (6 equiv) in CH2Cl2 for 1 h at room temperature afforded 4-alkyl (and aryl)-2-aryl-6-diazo-4H-thieno

Novel synthesis of cis-nickel(II) 3-alkylimino-3-alkyl(or aryl)thio-1-arylpropenethiolates and their application to the preparation of 5-aryl-3-(arylthio)isothiazoles

Treatment of (E)-3-alkylamino-3-alkylthio-1-(thioaroyl)propenes 2 with Ni(OAc)2·4H2O in EtOH at room temperature gave cis-Ni(II)-3-alkylimino-3-alkylthio-1-aryl- propenethiolates 3 in excellent yields. Heating a mixture of 3 and alkyl- or arylthiols in 1,2-dichloroethane gave new ketene S,N-acetals 4 having new alkyl- or arylthio groups depending on the thiols employed. For the first time, 5-aryl-3-(arylthio)isothiazoles were prepared from 2 with an arylthio group according to a known procedure.

A facile and convenient synthesis of 3-alkylamino-5-arylthiophenes with a variety of substituents at C-2 and studies of reaction mechanisms

Thioaroylketene S,N-acetals were treated with active methylene compounds including β-keto ester, nitromethane, cyanoacetic acid, p- toluenesulfonylacetone, 4-nitrophenylacetic acid, and diethyl (2- oxopropyl)phosphonate in the presence of mercury(II) acetate in CH2Cl2 at room temperature. These reactions gave 3-alkylamino-5-arylthiophenes containing various substituents, which comprised, respectively, alkoxycarbonyl, nitro, cyano, p-toluenesulfonyl, 4-nitrophenyl, and diethylphosphono groups at C-2 in good yields. The reaction of 3-methylamino- 3-methylthio-1-phenylthioxopropene with malonic acid or Meldrum's acid under the same conditions gave 3-methylamino-5-phenylthiophene. Similarly, treatment of 3-methylamino-3-methylthio-1-phenylthioxopropene with various enolizable cyclic ketones such as 4-hydroxy-6-methyl-2-pyrone, homophthalic anhydride, 2-hydroxy1,4-benzoquinone, and 1,3-diethyl-2-thiobarbituric acid gave thieno[3,2-b]pyridin-4-one, thieno[3,2c]isoquinolin-5-one, thieno[3,2- c]benzazepine-1,6-dione, and thieno[3,2-d]pyrimidine-2,4-dione, respectively.

THE REACTIONS OF ISOTHIAZOLIUM SALTS WITH NITROGEN NUCLEOPHILIC REAGENTS

Isothiazolium salts were allowed to react with a number of nitrogen nucleophiles including ammonia, hydrazine, phenylhydrazine, hydroxylamine, and benzylamine.The products obtained suggest that the position of initial nucleophilic attack is at the sulphur