5061-17-6

Usage

Derivative of

Benzohydrazide

Functional Groups

Indole group and benzoyl group

Potential Uses

Building block in synthesis of biologically active molecules
Potential antitumor and antiproliferative agent
Potential corrosion inhibitor for mild steel in acidic media
Versatile building block in synthesis of pharmaceuticals and other chemicals

Upstream product

• 91-56-5 indole-2,3-dione 
• 1904-58-1 anthranilic acid hydrazide 

Downstream Products

• 105096-01-3 dichloro(1-isatin-3-o-aminobenzoylhydrazone)cadmium 
• 105062-02-0 dichloro(1-isatin-3-o-aminobenzoylhydrazone)zinc(II) 

Relevant academic research and scientific papers

Co(II), Ni(II), Cu(II) and Zn(II) complexes of isatinyl-2-aminobenzoylhydrazone: Synthesis, characterization and anticancer activity

This article describes the synthesis, structural aspects and biological studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of a new hydrazone derived from the condensation of isatin and 2-aminobenzoylhydrazide. The ligand is well characterized using 1H NMR, 13C NMR, 2D HETCOR, mass and IR spectral studies. The chelating tendency of the ligand towards transition metal ions is established using analytical and spectral studies, which reveal the monobasic tridentate nature of the ligand. Octahedral geometry for Co(II), Cu(II) and Zn(II) and tetrahedral geometry for Ni(II) are tentatively proposed. All the synthesized compounds were screened for in vitro anticancer activity against Ehrlich ascites carcinoma and human cancer cell lines (adenocarcinoma HT29, kidney cancer cell line K293 and breast cancer cell line MDA231) using tryphan blue exclusion method and MTT assay.