50611-95-5Relevant academic research and scientific papers
A convenient and highly stereoselective synthesis of 4α-deuterio and -tritio steroids catalyzed by Pd
Rabinowitz
, p. 6081 - 6084 (2007/10/02)
A simple and highly stereoselective synthesis of [4α-2H]- and [4α-3H]-Δ5-3β-hydroxysteroids is presented. Palladium(O)-mediated borodeuteride reduction of readily-available cholest-5-en-3β,4β-diol cyclic carbonate provides [4α-2H]-Δ5-and Δ4-cholesterol in a 12:1 ratio. Reduction of [4α-3H]-cholest-5-ene-3β,4β-diol cyclic carbonate with NaB1H4 and Pd(O) resulted in [4β-3H]-cholesterol.
Stereochemistry of the Reduction of 3β-Benzoyloxycholest-5-en-4-one with Sodium Borohydride
Viger, Antoinette,Marquet, Andree,Barton, Derek H. R.,Motherwell, William B.,Zard, Samir Z.
, p. 1937 - 1940 (2007/10/02)
Reduction of 3β-benzoyloxycholest-5-en-4-one (3) with sodium borohydride under various conditions affords only minor amounts of 3β-benzoyloxycholest-5-en-4β-ol (2a).The major product is the 4α-isomer (6).Using sodium borodeuteride it has been shown that t
