50611-92-2Relevant academic research and scientific papers
Catalytic allylic oxidation with a recyclable, fluorous seleninic acid
Crich, David,Zou, Yekui
, p. 775 - 777 (2004)
In conjunction with iodoxybenzene as reoxidant perfluorooctylseleninic acid catalyzes the allylic oxidation of alkenes to enones in trifluoromethylbenzene at reflux in moderate to good yield. After a reductive workup with sodium metabisulfite, the catalyst is recovered by fluorous extraction in the form of bis(perfluorooctyl) diselenide, which, itself, serves as a convenient catalyst precursor.
Synthesis of [D4]- and [D7]-4β- hydroxycholesterols for use in a novel drug-drug interaction assay
Turley, Wesley A.,Burrell, Richard C.,Bonacorsi Jr., Samuel J.,Goodenough, Angela K.,Onorato, Joelle M.
scheme or table, p. 61 - 65 (2012/06/30)
Cytochrome P450 3A (CYP3A) enzymes are involved in the metabolism of over half of today's prescription drugs. As a result, drugs metabolized by CYP3A have a risk of drug-drug interactions (DDIs). Recent studies have shown the potential to use 4β-hydroxych
OXIDATION OF OLEFINS WITH 2-PYRIDINESELENINIC ANHYDRIDE
Barton, Derek H. R.,Crich, David
, p. 4359 - 4364 (2007/10/02)
2-Pyridineseleninic anhydride, prepared in situ by oxidation of the corresponding diselenide with iodoxybenzene, is an efficient reagent for the conversion of olefins to unsaturated ketones with retention of the original position of the double bond.This r
Stereochemistry of the Reduction of 3β-Benzoyloxycholest-5-en-4-one with Sodium Borohydride
Viger, Antoinette,Marquet, Andree,Barton, Derek H. R.,Motherwell, William B.,Zard, Samir Z.
, p. 1937 - 1940 (2007/10/02)
Reduction of 3β-benzoyloxycholest-5-en-4-one (3) with sodium borohydride under various conditions affords only minor amounts of 3β-benzoyloxycholest-5-en-4β-ol (2a).The major product is the 4α-isomer (6).Using sodium borodeuteride it has been shown that t
