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3-[(2-amino-6-chloropyrimidin-4-yl)amino]-5-(hydroxymethyl)cyclopentane-1,2-diol is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

50619-38-0

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50619-38-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 50619-38-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,6,1 and 9 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 50619-38:
(7*5)+(6*0)+(5*6)+(4*1)+(3*9)+(2*3)+(1*8)=110
110 % 10 = 0
So 50619-38-0 is a valid CAS Registry Number.

50619-38-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[(2-amino-6-chloropyrimidin-4-yl)amino]-5-(hydroxymethyl)cyclopentane-1,2-diol

1.2 Other means of identification

Product number -
Other names 3-(2-amino-6-chloro-pyrimidin-4-ylamino)-5-hydroxymethyl-cyclopentane-1,2-diol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:50619-38-0 SDS

50619-38-0Downstream Products

50619-38-0Relevant academic research and scientific papers

Novel substituted pyrimidines as HCV replication (replicase) inhibitors

Kwong, Cecil D.,Clark, Jeremy L.,Fowler, Anita T.,Geng, Feng,Kezar III, Hollis S.,Roychowdhury, Abhijit,Reynolds, Robert C.,Maddry, Joseph A.,Ananthan, Subramaniam,Secrist III, John A.,Shih, Neng-Yang,Piwinski, John J.,Li, Cheng,Feld, Boris,Huang, Hsueh-Cheng,Tong, Xiao,George Njoroge,Arasappan, Ashok

scheme or table, p. 1160 - 1164 (2012/03/11)

Compound 1 was identified as a HCV replication inhibitor from screening/early SAR triage. Potency improvement was achieved via modulation of substituent on the 5-azo linkage. Due to potential toxicological concern, the 5-azo linkage was replaced with 5-alkenyl or 5-alkynyl moiety. Analogs containing the 5-alkynyl linkage were found to be potent inhibitors of HCV replication. Further evaluation identified compounds 53 and 63 with good overall profile, in terms of replicon potency, selectivity and in vivo characteristics. Initial target engagement studies suggest that these novel carbanucleoside-like derivatives may inhibit the HCV replication complex (replicase).

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