5062-44-2Relevant academic research and scientific papers
REARRANGEMENT SPINAL DU DIMETHYL-4,4 EPOXY-6α,20α(5α)ANDROSTANE AVEC LE TRICHLORURE DE BORE
Fetizon, Marcel,Sozzi, Georges
, p. 61 - 68 (1981)
A backbone rearrangement of 4,4 dimethyl 6α,20α epoxy (5α)androstane with BCl3 is described.The structures of the resulting compounds have been elucidated either by synthesis from 3β-acetoxy (5α)pregnane 20-one, or by X rays diffraction.
COMPOUNDS INCLUDING AN ANTI-INFLAMMATORY PHARMACORE AND METHODS OF USE
-
Page/Page column 132, (2009/12/27)
This invention provides novel compounds comprising the following anti-inflammatory pharmacore Formula (I): wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
Synthesis and Carbon-13 Nuclear Magnetic Resonance Studies of Δ5 and Saturated 4,4-Disubstituted 3-Ketosteroids
Rizvi, Syed Q. A.,Williams, John R.
, p. 1127 - 1132 (2007/10/02)
A number of Δ5-4,4-dialkyl-3-ketosteroids were synthesized by alkylation of steroidal 4-en-3-ones via their enolate anions.Carbon-13 nuclear magnetic resonance spectra of these compounds were measured and assigned.Predicted carbon shifts show fairly good agreement with the observed values in the estrenone series.The deviations for androstenones and cholestenones were interpreted in terms of conformational changes in the steroid skeleton which arise from nonbonded 1,5-interactions (δ-effect) between the 19-methyl and the 4,4 substituents.Comparison of the carbon shifts for 4,4-dimethyl-3-ketosteroids with the appropriate Δ5derivatives did not indicate any "conformational transmission" in the latter compounds.The observed carbon shift differences for C-14 seem to arise solely from the presence of the 19-methyl group.
