50625-79-1

Basic information

• Product Name: N-(2-methylbenzyl)aniline
• Synonyms: N-(2-methylbenzyl)aniline
• CAS NO: 50625-79-1
• Molecular Weight: 197.28
• Mol File: 50625-79-1.mol
• Article Data: 86

Chemical Properties

• CAS DataBase Reference: N-(2-methylbenzyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methylbenzyl)aniline(50625-79-1)
• EPA Substance Registry System: N-(2-methylbenzyl)aniline(50625-79-1)

Safety Data

• Hazardous Substances Data: 50625-79-1(Hazardous Substances Data)

Upstream product

• 10228-77-0 N-(o-methylbenzylidene)aniline 
• 19375-67-8 2-phenylisoindoline 
• 89-95-2 2-methyl-benzyl alcohol 
• 98-95-3 nitrobenzene 
• 529-20-4 2-methylphenyl aldehyde 
• 62-53-3 aniline 
• 89-93-0 ortho-methylbenzylamine 
• 1527-91-9 N-phenylbenzamidine 
• 591-50-4 iodobenzene 
• 108-90-7 chlorobenzene 
• 108-86-1 bromobenzene 
• 89-92-9 2-methylbenzyl bromide 
• 64-10-8 phenyl carbamate 
• 552-45-4 1-chloromethyl-2-methylbenzene 

Downstream Products

• 1611494-93-9 N¹,N³-bis(2-methylbenzyl)-N¹,N³-diphenylmalonamide 
• 19375-67-8 2-phenylisoindoline 

Relevant articles and documents

Selective C-C bonds formation, N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite

Earth abundant metals are much less expensive, promising, valuable metals and could be served as catalysts for the borrowing hydrogen reaction, dehydrogenation and heterocycles synthesis, instead of noble metals. The uniformly dispersed zinc composites were designed, synthesized and carefully characterized by means of XPS, EDS, TEM and XRD. The resulting zinc composite showed good catalytic activity for the N-alkylation of amines with amines, ketones with alcohols in water under base-free conditions, while unsaturated carbonyl compounds could also be synthesized by tuning the reaction conditions. Importantly, it was the first time to realize the synthesis of 2-aryl-1H-benzo[d]imidazole derivatives by using this zinc composite under green conditions. Meanwhile, this zinc catalyst could be easily recovered and reused for at least five times.

Photocatalytic one-pot multidirectional N-alkylation over Pt/D-TiO2/Ti3C2: Ti3C2-based short-range directional charge transmission

Visible-light-induced one-pot, multistep, and chemoselectivity adjustable reactions highlight the economical, sustainable, and green process. Herein, we report Pt nanoparticles dispersed on S and N co-doped titanium dioxide/titanium carbide (MXene) (3%Pt/

Ruthenium(ii) complexes with N-heterocyclic carbene-phosphine ligands for theN-alkylation of amines with alcohols

Metal hydride complexes are key intermediates forN-alkylation of amines with alcohols by the borrowing hydrogen/hydrogen autotransfer (BH/HA) strategy. Reactivity tuning of metal hydride complexes could adjust the dehydrogenation of alcohols and the hydrogenation of imines. Herein we report ruthenium(ii) complexes with hetero-bidentate N-heterocyclic carbene (NHC)-phosphine ligands, which realize smart pathway selection in theN-alkylated reactionviareactivity tuning of [Ru-H] species by hetero-bidentate ligands. In particular, complex6cbwith a phenyl wingtip group and BArF?counter anion, is shown to be one of the most efficient pre-catalysts for this transformation (temperature is as low as 70 °C, neat conditions and catalyst loading is as low as 0.25 mol%). A large variety of (hetero)aromatic amines and primary alcohols were efficiently converted into mono-N-alkylated amines in good to excellent isolated yields. Notably, aliphatic amines, challenging methanol and diamines could also be transformed into the desired products. Detailed control experiments and density functional theory (DFT) calculations provide insights to understand the mechanism and the smart pathway selectionvia[Ru-H] species in this process.