50627-25-3

Basic information

• Product Name: 2-Amino-3-cyano-5-phenylpyrazine
• Synonyms: 2-Amino-3-cyano-5-phenylpyrazine;Pyrazinecarbonitrile, 3-aMino-6-phenyl-;3-Amino-6-phenylpyrazine-2-carbonitrile
• CAS NO: 50627-25-3
• Molecular Formula: C₁₁H₈N₄
• Molecular Weight: 196.21
• Mol File: 50627-25-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Amino-3-cyano-5-phenylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-cyano-5-phenylpyrazine(50627-25-3)
• EPA Substance Registry System: 2-Amino-3-cyano-5-phenylpyrazine(50627-25-3)

Safety Data

• Hazardous Substances Data: 50627-25-3(Hazardous Substances Data)

Usage

General Description

2-Amino-3-cyano-5-phenylpyrazine is a chemical compound with the molecular formula C11H8N4. It is a pyrazine derivative that contains an amino group, a cyano group, and a phenyl group. 2-Amino-3-cyano-5-phenylpyrazine has potential applications in the development of pharmaceuticals and other organic compounds due to its unique chemical structure and properties. It may also be utilized as a building block for the synthesis of other complex molecules. 2-Amino-3-cyano-5-phenylpyrazine is of interest to researchers and scientists for its potential uses in various fields such as medicinal chemistry, materials science, and organic synthesis.

Upstream product

• 67602-05-5 2-amino-3-bromo-5-phenylpyrazine 
• 50627-20-8 2-amino-3-cyano-5-phenylpyrazine-1-N-oxide 
• 532-54-7 oxo-phenyl-acetaldehyde oxime 

Downstream Products

• 900508-49-8 4-chloro-2-dimethylamino-6-phenylpteridine 
• 272130-24-2 methyl 3-amino-6-phenylthieno[2,3-b]pyrazine-2-carboxylate 
• 1173998-94-1 C₁₁H₁₂N₄ 

Relevant articles and documents

A scaleable synthesis of fiduxosin

Fiduxosin (1) has been under development at Abbott Laboratories for the treatment of benign prostatic hyperplasia. A convergent strategy required methodologies for preparation of an enantiomerically pure 3,4-cis-disubstituted pyrrolidine and a 2,3,5-trisubstituted thienopyrazine in a regiospecific manner. A [3+2] cycloaddition of an enantiopure azomethine ylide followed by a diastereoselective crystallization was employed to prepare the benzopyranopyrrolidine in high diastereomeric and enantiomeric purity. Conditions for reduction of an O-aryl lactone susceptible to epimerization were developed, and cyclization of the alcohol/phenol to the ether was accomplished in high yield. The thienopyrazine was prepared by condensation of methyl thioglycolate and a regiospecifically prepared 2-bromo-3-cyano-5-phenylpyrazine. Conditions for effective halogen substitutive deamination to prepare regiospecific trisubstituted pyrazines will be described.