50640-01-2Relevant academic research and scientific papers
Nickel-Catalyzed Regioselective Cross-Dehydrogenative Coupling of Inactive C(sp3)-H Bonds with Indole Derivatives
Jin, Li-Kun,Wan, Li,Feng, Jie,Cai, Chun
supporting information, p. 4726 - 4729 (2015/10/12)
A nickel-catalyzed regiosepecific C2- versus C3-oxidative cross-coupling reaction of indoles with 1,4-dioxane and other inactive C(sp3)-H bonds is described. The divergent synthesis of C(sp3)-C(sp2) bonds was achieved in satisfactory yields with di-tert-butyl peroxide (DTBP) as the oxidant, which provides an efficient strategy for the selective construction of cyclic ethers containing heteroaromatic core structures.
