506421-62-1

Basic information

• Product Name: 2-(4-TrifluoroMethyl-phenyl)-quinoline
• Synonyms: 2-(4-TrifluoroMethyl-phenyl)-quinoline
• CAS NO: 506421-62-1
• Molecular Formula: C₁₆H₁₀F₃N
• Molecular Weight: 273.2525096
• Mol File: 506421-62-1.mol
• Article Data: 55

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-TrifluoroMethyl-phenyl)-quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-TrifluoroMethyl-phenyl)-quinoline(506421-62-1)
• EPA Substance Registry System: 2-(4-TrifluoroMethyl-phenyl)-quinoline(506421-62-1)

Safety Data

• Hazardous Substances Data: 506421-62-1(Hazardous Substances Data)

Usage

General Description

2-(4-TrifluoroMethyl-phenyl)-quinoline is a chemical compound with the molecular formula C18H12F3N. It is a quinoline derivative that contains a 4-trifluoromethylphenyl group attached to the quinoline structure. 2-(4-TrifluoroMethyl-phenyl)-quinoline has potential applications in pharmaceutical research and drug discovery, as quinoline derivatives have been found to possess various biological activities, including anticancer, antimicrobial, and anti-inflammatory properties. The addition of the 4-trifluoromethylphenyl group to the quinoline structure can potentially enhance the compound's pharmacological properties and improve its biological activity. Further research and studies are needed to explore the potential uses and effects of 2-(4-TrifluoroMethyl-phenyl)-quinoline in various applications.

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 62-53-3 aniline 
• 79-10-7 acrylic acid 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 4403-69-4 2-amino-1-benzylamine 
• 5344-90-1 2-Aminobenzyl alcohol 
• 1737-26-4 1-(4-trifluorophenyl)ethanol 
• 2005-43-8 2-bromoquinoline 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 1813-97-4 1-allyl-4-(trifluoromethyl)benzene 
• 91-22-5 quinoline 
• 368-94-5 4-trifluoromethyl-benzoyl fluoride 
• 271-58-9 anthranil 
• 705-31-7 4-trifluoromethylphenylacetylene 

Downstream Products

• 1198359-51-1 (R)-2-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroquinoline 
• 1198359-68-0 2-(4-trifluoromethylphenyl)quinoline hydrobromide 

Relevant articles and documents

Visible-Light-Mediated Oxidative Cyclization of 2-Aminobenzyl Alcohols and Secondary Alcohols Enabled by an Organic Photocatalyst

This paper describes a visible-light-mediated oxidative cyclization of 2-aminobenzyl alcohols and secondary alcohols to produce quinolines at room temperature. This photocatalytic method employed anthraquinone as an organic small-molecule catalyst and DMSO as an oxidant. According to this present procedure, a series of quinolines were prepared in satisfactory yields.

Direct C-H Arylation and Alkylation of Electron-Deficient Heteroaromatic Compounds with Organozinc Reagents

A direct and convenient method for the C-H arylation and alkylation of electron-deficient N-heteroarenes with readily available organozinc reagents has been developed. This transformation could be readily performed in the absence of a transition-metal catalyst and external oxidants, affording a wide range of substituted heteroarenes with good functional group tolerance in good to excellent yields. The developed simple protocol is scalable to the gram level and suitable for late-stage modification of bioactive molecules and drugs.

Ruthenium-catalyzed acceptorless dehydrogenative coupling of o-aminobenzyl alcohols with ketones to quinolines in the presence of carbonate salt

A ruthenium complex bearing a functional 2,2′-bibenzimidazole ligand [(p-cymene)Ru(BiBzImH2)Cl][Cl] was designed, synthesized and found to be a general and highly efficient catalyst for the synthesis of quinolines via acceptorless dehydrogenative coupling of o-aminobenzyl alcohols with ketones in the presence of carbonate salt. It was confirmed that NH units in the ligand are crucial for catalytic activity. The application of this catalytic system for the scale-gram synthesis of biologically active molecular was also undertaken. Notably, this research exhibits new potential of metal–ligand bifuctional catalysts for acceptorless dehydrogenative reactions.