506423-84-3Relevant academic research and scientific papers
Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds
Lumangtad, Liezel A.,Claeys, Elisa,Hamal, Sunil,Intasiri, Amarawan,Basrai, Courtney,Yen-Pon, Expedite,Beenfeldt, Davison,Vermeire, Kurt,Bell, Thomas W.
, (2020/11/20)
CADA compounds selectively down-modulate human cell-surface CD4 protein and are of interest as HIV entry inhibitors and as drugs for asthma, rheumatoid arthritis, diabetes and some cancers. Postulating that fusing a pyridine ring bearing hydrophobic subst
Concave pyridines with extended π-systems
Storm, Ole,Luening, Ulrich
, p. 3680 - 3685 (2007/10/03)
New 4-substituted concave pyridines 1b-d have been synthesised as precursors to allow extension of the pyridine π-system. With the Sonogashira coupling as the key synthetic step, the 4-iodo pyridine 1c was coupled with phenylacetylene (11) to give 1g in 77% yield. Because of its conjugated π system, the new concave pyridine 1g has UV absorption maxima at λmax1 = 286 nm and λmax2 = 303 nm with εmax1 = 43300 Lmol-1cm-1 and εmax2 = 39300 Lmol-1cm-1, respectively, allowing its potential application as a sensor. ( Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).
