506436-30-2

Upstream product

• 105-53-3 diethyl malonate 
• 3288-15-1 diethyl (4-methoxyphenyl)thiocarbamoylmalonate 
• 4548-45-2 2-chloro-5-nitropyridine 
• 506436-24-4 ethyl 3-(4-methoxyphenyl)amino-5-oxo-2,5-dihydroisoxazole-4-carboxylate 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 

Relevant academic research and scientific papers

Rearrangements of 2-pyridyl-3-arylaminoisoxazol-5(2H)-ones to imidazo[1,2-a]pyridines under flash-vacuum-pyrolysis

2-Pyridyl-3-arylaminoisoxazol-5(2H)-ones, rearranged under flash-vacuum-pyrolysis (FVP) conditions accompanied by elimination of carbon dioxide to give imidazo[1,2-a]pyridines in high to excellent yields (85-95 %).

Synthesis of 2-(5-nitropyrid-2-yl)-3-(4-substitutedphenyl)aminoisoxazol- 5(2h)-ones and their rearrangements to imidazo[1,2-a]-pyridines and indoles with triethylamine

3-(4-Substitutedphenyl)aminoisoxazol-5(2H)-ones, substituted on nitrogen with a nitropyridine group, react with triethylamine to give imidazo[1,2-a]pyridines and indoles. With 4-bromophenyl and 4-methylphenyl group substituents only imidazopyridines are f

2-Aryl-3-arylaminoisoxazol-5(2H)-ones as sources of indoles and imidazo[1,2-a]pyridines

2-Aryl-3-arylaminoisoxazol-5(2H)-ones undergo solvolysis to form 1,3-dipoles that undergo intramolecular cyclisation to form either imidazopyridines or indoles. The mode of cyclisation is controlled by the electronegativity of the aryl substituents.