50650-76-5

Basic information

• Product Name: Piroctone
• Synonyms: Piroctone;1-Hydroxy-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)-pyridon piroctone;1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone
• CAS NO: 50650-76-5
• Molecular Formula: C₁₄H₂₃NO₂
• Molecular Weight: 237.34
• Mol File: 50650-76-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 108 ºC
• Boiling Point: 344.1 °C at 760 mmHg
• Flash Point: 161.9 °C
• Appearance: /
• Density: 1.029
• Vapor Pressure: 4.31E-06mmHg at 25°C
• Refractive Index: 1.512
• PKA: 6.21±0.58(Predicted)
• CAS DataBase Reference: Piroctone(CAS DataBase Reference)
• NIST Chemistry Reference: Piroctone(50650-76-5)
• EPA Substance Registry System: Piroctone(50650-76-5)

Safety Data

• Hazardous Substances Data: 50650-76-5(Hazardous Substances Data)

Usage

Uses

Antiseborrheic.

Definition

ChEBI: A cyclic hydroxamic acid that consists of 1-hydroxypyridin-2-one bearing methyl and 2,4,4-trimethylpentyl substtituents at positions 4 and 6 respectively.

Brand name

Octopirox (Hoechst AG, Germany).

InChI:InChI=1/C14H23NO2/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5/h6,8,11,17H,7,9H2,1-5H3

Upstream product

• 36727-29-4 isononanoyl chloride 
• 924-50-5 Methyl 3,3-dimethylacrylate 
• 68890-66-4 piroctone olamine 
• 504-29-0 2-aminopyridine 
• 50650-75-4 4-methyl-6-(2,4,4-trimethylpentyl)-2H-pyran-2-one 

Downstream Products

• 68890-66-4 piroctone olamine 

Relevant articles and documents

Preparation process of pyridinone ethanol amine salt

The invention relates to the technical field of pyridone ethanol amine salt processing, and particularly discloses a pyridone ethanol amine salt preparation process, which comprises: carrying out an acylation reaction, a ring-closure reaction, a hydroxyamination reaction and a salt forming reaction on 3,3-dimethyl acrylate and isononyl chloride to obtain pyridone ethanol amine salt; wherein the acylation reaction is carried out in the presence of a supported catalyst, the supported catalyst comprises an active component and a carrier, the carrier is silica gel, the active component comprises anhydrous aluminum chloride, anhydrous lanthanum chloride and anhydrous lithium perchlorate, and the loading capacity of anhydrous aluminum chloride on the carrier is 7-11 wt%; the loading capacity ofanhydrous lanthanum chloride on the carrier is 3-5 wt%; and the loading capacity of anhydrous lithium perchlorate on the carrier is 0.8-1.5 wt%. According to the preparation process of pyridinone ethanol amine salt, the catalytic Friedel-Crafts acylation reaction is realized, the supported catalyst is convenient to recover, and the activity and selectivity of the supported catalyst are improved.

Preparation method of pyridinone ethanolamine salt

The invention discloses a preparation method of a pyridinone ethanolamine salt. The preparation method comprises the reaction steps of Friedel-Crafts acylation, ring closing, hydroxyamination, salification and the like. According to the preparation method, the pyridinone ethanolamine salt can be efficiently prepared under mild conditions, less reaction materials are consumed, the yield and purityof products obtained in the steps are high, and complex purification steps are not needed.

PROCESS FOR FORMING 2-HYDROXYPYRIDINE-1-OXIDE OR DERIVATIVES THEREOF

A process for forming 2-hydroxypyridine-1 -oxide or derivatives thereof, the process comprising inter alia providing a solution comprising at least one compound according to Formula (1) (I) and recovering a compound according to Formula (2) (2) Also related products, uses, methods and compositions.