50654-43-8Relevant academic research and scientific papers
Synthesis of Spirocyclic β- and γ-Sultams by One-Pot Reductive Cyclization of Cyanoalkylsulfonyl Fluorides
Stepannikova, Kateryna O.,Vashchenko, Bohdan V.,Grygorenko, Oleksandr O.,Gorichko, Marian V.,Cherepakha, Artem Yu.,Moroz, Yurii S.,Volovenko, Yulian M.,Zhersh, Serhii
, p. 6530 - 6540 (2020/05/25)
One-pot intramolecular cyclization of novel sp3-enriched cyanoalkylsulfonyl fluorides into spirocyclic β- or γ-sultams is disclosed. The method relies on nitrile group reduction followed by sulfonylation of amino group thus formed upon mild con
Use of a Catalytic Chiral Leaving Group for Asymmetric Substitutions at sp3-Hybridized Carbon Atoms: Kinetic Resolution of β-Amino Alcohols by p-Methoxybenzylation
Kuroda, Yusuke,Harada, Shingo,Oonishi, Akinori,Kiyama, Hiroki,Yamaoka, Yousuke,Yamada, Ken-Ichi,Takasu, Kiyosei
supporting information, p. 13137 - 13141 (2016/10/30)
A catalytic strategy was developed for asymmetric substitution reactions at sp3-hybridized carbon atoms by using a chiral alkylating agent generated in situ from trichloroacetimidate and a chiral phosphoric acid. The resulting chiral p-methoxybenzyl phosphate selectively reacts with β-amino alcohols rather than those without a β-NH functionality. The use of an electronically and sterically tuned chiral phosphoric acid enables the kinetic resolution of amino alcohols through p-methoxybenzylation with good enantioselectivity.
BENZISOXAZOLE COMPOUND
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Page/Page column 70, (2009/02/10)
Disclosed is a compound represented by the general formula (I) or a salt thereof: wherein any one of R1, R2 and R3 represents a group represented by the formula: -(CH2)m-NR11R12 (wherein m is 1 or 2; and R11 and R12 independently represent a hydrogen atom or a C1-6 alkyl group or may, together with a nitrogen atom to which R11 and R12 are bound, form a 4- or 5-membered cyclic group); the remaining two or R1, R2 and R3 independently represent a group represented by the formula: -(O)n-R21 (wherein n is 0 or 1; and R21 represents a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or the like); and R4 represents a C1-6 alkyl group which may have a substituent or the like.
A NOVEL SYNTHESIS OF 3,3-(SPIRO)SUBSTITUTED AZETIDINES
Froehlich, Johannes,Sauter, Fritz,Blasl, Karin
, p. 1879 - 1892 (2007/10/02)
A smooth and efficient new synthesis for 3,3-disubstituted azetidines, starting from readily available nitriles, was estabilished: α-hydroxymethylation of the starting materials, followed by O-tosylation and LiAlH4-reduction of the key intermediates thus obtained, led - via spontaneous cyclization of the intermediate amino derivatives - to 3,3-disubstituted azetidines.Scope and limitations of this new method were studied with respect to generalized applicability: the target compounds were accessible in good yields for a variety of starting materials (cyclic and acyclic di(hetero)aryl, (hetero)arylalkyl, dialkyl, as well as basic moieties).The products thus obtained may be of interest for ensuing conversions due to their unblocked nitrogen.
THIOL ESTERS IN ORGANIC SYNTHESIS. XI. A FACILE APPROACH TO β-HYDROXYPROPIONITRILES AND ACRYLONITRILES. CYANOTHIOLACETATE AS MASKED β-HYDROXYPROPIONITRILE CARBANION
Liu, Hsing-Jang,Wynn, Hla
, p. 3151 - 3154 (2007/10/02)
The preparation of β-hydroxypropionitriles and acrylonitriles is facilitated by the use of cyanothiolacetate as a formal equivalent of β-hydroxypropionitrile carbanion.
