50667-69-1

Usage

Uses

Used in Pharmaceutical Industry:
N-(HYDROXYMETHYL)TRIFLUOROACETAMIDE is used as an intermediate compound for the synthesis of various drug molecules, particularly those targeting specific enzymes or receptors in the body. Its unique structural features make it a valuable building block in the development of new medications.
Used in the Preparation of mPGES-1 Inhibitors:
N-(HYDROXYMETHYL)TRIFLUOROACETAMIDE is used as a key component in the process for the preparation of chlorooxotrifluoromethylphenyldihydrotriazolylbenzylpivalamide polymorphs. These polymorphs serve as inhibitors of the enzyme microsomal prostaglandin E synthase-1 (mPGES-1), which plays a role in the production of prostaglandins, important signaling molecules in the body. Inhibition of mPGES-1 can help in the treatment of various inflammatory conditions and pain management.

InChI:InChI=1/C3H4F3NO2/c4-3(5,6)2(9)7-1-8/h8H,1H2,(H,7,9)

Upstream product

• 50-00-0 formaldehyd 
• 354-38-1 2,2,2-trifluoroacetamide 
• 176504-61-3 N,N'-bis(trifluoroacetyl)methanediamine 

Downstream Products

• 93135-39-8 2-<(trifluoroacetamido)methyl>-4-nitrophenol 
• 185455-02-1 2,2,2-Trifluoro-N-{2-methoxy-5-nitro-3-[(2,2,2-trifluoro-acetylamino)-methyl]-benzyl}-acetamide 
• 717122-44-6 N-[(4-chloro-2,5-dimethoxy-3,6-dimethylphenyl)methyl]-2,2,2-trifluoroacetamide 
• 717122-46-8 N-[(6-chloro-2,5-dimethoxy-3,4-dimethylphenyl)methyl]-2,2,2-trifluoroacetamide 
• 717122-45-7 N-[(3-chloro-2,5-dimethoxy-4,6-dimethylphenyl)methyl]-2,2,2-trifluoroacetamide 
• 864515-01-5 N-[(2,5-dimethoxy-4,6-dimethylphenyl)methyl]-2,2,2-trifluoroacetamide 
• 1449737-66-9 2-chloro-4-fluoro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid 
• 1449737-67-0 2-chloro-4-fluoro-3-((2,2,2-trifluoroacetamido)methyl)benzoic acid 
• 1294552-12-7 3-aminomethyl-2-chloro-6-methylbenzoic acid 
• 1294552-13-8 3-aminomethyl-2-methyl-6-chlorobenzoic acid 
• 1427158-48-2 methyl 2-chloro-6-methyl-3-(pivalamidomethyl)benzoate 
• 1427158-49-3 methyl 6-chloro-2-methyl-3-(pivalamidomethyl)benzoate 
• 1427158-46-0 methyl 3-(((tert-butoxycarbonyl)amino)methyl)-2-chloro-6-methylbenzoate 

Relevant academic research and scientific papers

Reactions of trifluoromethanesulfonamide with amides and paraformaldehyde

Two- and three-component condensations of paraformaldehyde with trifluoromethanesulfonamide, acetamide, trifluoroacetamide, 1H-benzotriazole, methanesulfonamide, and malonamide were studied. N-Hydroxymethyl derivatives of trifluoroacetamide and 1H-benzotriazole reacted with trifluoromethanesulfonamide to give N-(trifluoroacetylaminomethyl)- and N-(1H-benzotriazol-1-ylmethyl)- substituted derivatives of tri-fluoromethanesulfonamide, as well as N,N'-methylenebis(trifluoromethylsulfonamide) and N-(trifluoromethyl- sulfonylaminomethyl)trifluoroacetamide as transamination products. Three-component condensation of trifluoromethanesulfonamide with paraformaldehyde and methanesulfonamide led to the formation of 1-methylsulfonyl-3,5-bis(trifluoromethylsulfonyl)hexahydro-1,3,5-triazine, and the reaction of trifluoromethanesulfonamide with paraformaldehyde and malonamide gave 4,10-bis(trifluoromethylsulfonyl)-2,4,8,10-tetraazaspiro-[5.5]undecane-1, 7-dione whose structure was proved by X-ray analysis.

A compound and its preparation process and method for producing a polypeptide using the same

The invention discloses a compound, a preparation method thereof and a method for preparing a polypeptide by virtue of the compound. The compound has the structure specified in the description, wherein the N-terminal cysteine of the polypeptide can be protected by virtue of the compound, thus shielding the activity of the N-terminal cysteine, then connection for more (greater than or equal to 3) polypeptide segments can be realized when the polypeptide segments are connected to prepare proteins, i.e., separation and purification treatment is not needed after every two polypeptide segments are connected, and connection with the next polypeptide segment can be directly carried out after the shielding is removed.

An efficient one-pot four-segment condensation method for protein chemical synthesis

Successive peptide ligation using a one-pot method can improve the efficiency of protein chemical synthesis. Although one-pot three-segment ligation has enjoyed widespread application, a robust method for one-pot four-segment ligation had to date remained undeveloped. Herein we report a new one-pot multisegment peptide ligation method that can be used to condense up to four segments with operational simplicity and high efficiency. Its practicality is demonstrated by the one-pot four-segment synthesis of a plant protein, crambin, and a human chemokine, hCCL21. Pick up a peptide: Tfacm-protected cysteine is readily activated by pH adjustment, enabling the development of a highly efficient one-pot four-segment ligation method. Two proteins, crambin and the chemokine hCCL21, are prepared using this rapid and high-yielding synthetic route.

A simple and efficient preparation of novel formaldehyde derivatives

New formaldehyde derivatives were prepared in good yields by a short and versatile route. Several crystal structures of corresponding thioacetic acid esters and thiols were determined. The thioacetates were cleaved under acidic or basic conditions affording the thiols in high yield, thus introducing the new substance classes of N-mercaptomethyl-alkylcarboxamides, N-mercapto- methylsulfonamides, and alkoxymethanethiols. Georg Thieme Verlag Stuttgart New York.