50675-20-2

Usage

Uses

Used in Pharmaceutical Industry:
Piperidine-4-carbaldehyde serves as a crucial building block in the synthesis of various pharmaceuticals. Its chemical properties allow for the development of new drug molecules, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, Piperidine-4-carbaldehyde is utilized in the production of agrochemicals, playing a significant role in the development of compounds that protect crops and enhance agricultural productivity.
Used in Fine Chemicals Production:
Piperidine-4-carbaldehyde is also employed as an intermediate in the manufacturing of fine chemicals, particularly in the creation of flavor and fragrance compounds that are used in the food, beverage, and cosmetic industries.
Used in Research Applications:
Piperidine-4-carbaldehyde is utilized in research settings for the exploration and development of new materials and drug molecules, underpinning scientific innovation and discovery in the chemical and related fields.
It is imperative to handle Piperidine-4-carbaldehyde with care due to its toxic nature, ensuring that proper safety measures are implemented during its use in various applications.

InChI:InChI=1/C6H11NO/c8-5-6-1-3-7-4-2-6/h5-7H,1-4H2

Upstream product

• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 1126-09-6 4-carbethoxypiperidine 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 6457-49-4 4-piperidinemethanol 

Downstream Products

• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 1440753-53-6 N-benzyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)acetamide 
• 24686-78-0 1-Benzoyl-4-piperidone 
• 120014-29-1 1-benzoyl-piperidine-4-carboxaldehyde 
• 553666-09-4 1-[(4-methylphenyl)sulfonyl]piperidine-4-carbaldehyde 
• 1565836-09-0 1-(3-methylbenzyl)-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole 
• 1565836-10-3 1-(4-fluorobenzyl)-2-(4-(2-(2-phenyl-1H-benzo[d]imidazol-1-yl)-2-(piperidin-4-yl)ethoxy)phenyl)-1H-benzo[d]imidazole 
• 1440754-12-0 C₄₀H₃₇N₅O 
• 1565835-83-7 2-phenyl-1-(1-(piperidin-4-yl)-2-(4-(1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-2-yl)phenoxy)ethyl)-1H-benzo[d]imidazole 
• 676517-65-0 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-phenyl-1-piperidineacetic acid 
• 1169549-73-8 8-bromo-2-{2-chloro-4-[(piperidin-4-ylmethyl)amino]phenyl}[1]benzofuro[3,2-d]pyrimidin-4(3H)-one 

Relevant academic research and scientific papers

ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS

A compound of Formula (I) or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

Cobalt-Catalyzed Aerobic Oxidative Cleavage of Alkyl Aldehydes: Synthesis of Ketones, Esters, Amides, and α-Ketoamides

A widely applicable approach was developed to synthesize ketones, esters, amides via the oxidative C?C bond cleavage of readily available alkyl aldehydes. Green and abundant molecular oxygen (O2) was used as the oxidant, and base metals (cobalt and copper) were used as the catalysts. This strategy can be extended to the one-pot synthesis of ketones from primary alcohols and α-ketoamides from aldehydes.

Novel spiroketal pyrrolidine GSK2336805 potently inhibits key hepatitis C virus genotype 1b mutants: From lead to clinical compound

Rapid clinical progress of hepatitis C virus (HCV) replication inhibitors, including these selecting for resistance in the NS5A region (NS5A inhibitors), promises to revolutionize HCV treatment. Herein, we describe our explorations of diverse spiropyrrolidine motifs in novel NS5A inhibitors and a proposed interaction model. We discovered that the 1,4-dioxa-7-azaspiro[4.4]nonane motif in inhibitor 41H (GSK2236805) supported high potency against genotypes 1a and 1b as well as in genotype 1b L31V and Y93H mutants. Consistent with this, 41H potently suppressed HCV RNA in the 20-day RNA reduction assay. Pharmacokinetic and safety data supported further progression of 41H to the clinic.

Highly chemoselective aerobic oxidation of amino alcohols into amino carbonyl compounds

The direct oxidation of unprotected amino alcohols to their corresponding amino carbonyl compounds has often posed serious challenges in organic synthesis and has constrained chemists to adopting an indirect route, such as a protection/deprotection strategy, to attain their goal. Described herein is a highly chemoselective aerobic oxidation of unprotected amino alcohols to their amino carbonyl compounds in which 2-azaadamantane N-oxyl (AZADO)/copper catalysis is used. The catalytic system developed leads to the alcohol-selective oxidation of various unprotected amino alcohols, carrying a primary, secondary, or tertiary amino group, in good to high yield at ambient temperature with exposure to air, thus offering flexibility in the synthesis of nitrogen-containing compounds. Strong as an ox: The highly chemoselective aerobic oxidation of unprotected amino alcohols to their corresponding amino carbonyl compounds has been achieved by using 2-azaadamantane N-oxyl (AZADO)/copper catalysis. This catalytic system oxidizes not only alcohols with tertiary amino groups but also those with secondary and primary amines in good to high yield at ambient temperature in air. bpy=2,2-bipyridyl, DMAP=4-(N,N-dimethylamino)pyridine.

Studies on new platelet aggregation inhibitors 1. Synthesis of 7-nitro-3,4-dihydroquinoline-2(1H)-one derivatives

A series of 6-cyclic aliphatic amino-7-nitro-3,4-dihydroquinoline-2(1H)-ones were prepared and tested for platelet aggregation inhibitory effect, cardiotonic activity and chronotropic activity. These compounds appeared to show selective inhibitory activity against platelet aggregation. Among them, 6-(4-ethoxycarbonylpiperidino)-7-nitro-3,4-dihydroquinoline-2(1H)-one (22f) showed the most potent inhibitory activity and high selectivity. A divergent synthetic route to 6-cyclic aliphatic amino-7-nitro-3,4-dihydroquinoline-2(1H)-one derivatives has also been investigated.