1440754-12-0 Usage
Molecular Structure
1H-Benzimidazole, 2-[4-[2-(2-phenyl-1H-benzimidol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)has a complex molecular structure containing benzimidazole, phenyl, piperidine, and ethoxy groups.
Aromatic System
The compound is characterized by a large aromatic system, which contributes to its stability and potential pharmacological activities.
Benzimidazole Group
The presence of the benzimidazole group provides a stable, planar structure that can participate in various chemical reactions and interactions.
Phenyl Group
The phenyl group contributes to the compound's aromaticity and can influence its solubility, stability, and pharmacokinetic properties.
Piperidine Group
The piperidine group is a nitrogen-containing, heterocyclic structure that can participate in hydrogen bonding and coordination with other molecules, potentially affecting the compound's pharmacological activity.
Ethoxy Group
The ethoxy group is an alkoxy substituent that can influence the compound's solubility, stability, and lipophilicity, which may be important for its pharmacokinetic properties and bioavailability.
Medicinal Chemistry Applications
Due to its structural features and potential pharmacological activities, 1H-Benzimidazole, 2-[4-[2-(2-phenyl-1H-benzimidol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)has potential applications in medicinal chemistry and drug design.
Further Study and Analysis
The specific properties and potential uses of 1H-BenziMidazole, 2-[4-[2-(2-phenyl-1H-benziMidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylMethyl)- would require further study and analysis to fully understand its potential in drug development and therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1440754-12-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,0,7,5 and 4 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1440754-12:
(9*1)+(8*4)+(7*4)+(6*0)+(5*7)+(4*5)+(3*4)+(2*1)+(1*2)=140
140 % 10 = 0
So 1440754-12-0 is a valid CAS Registry Number.
1440754-12-0Relevant academic research and scientific papers
Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site
Zimmermann, Gunther,Schultz-Fademrecht, Carsten,Küchler, Philipp,Murarka, Sandip,Ismail, Shehab,Triola, Gemma,Nussbaumer, Peter,Wittinghofer, Alfred,Waldmann, Herbert
, p. 5435 - 5448 (2014/07/08)
K-Ras is one of the most frequently mutated signal transducing human oncogenes. Ras signaling activity requires correct cellular localization of the GTPase. The spatial organization of K-Ras is controlled by the prenyl binding protein PDEδ, which enhances Ras diffusion in the cytosol. Inhibition of the Ras-PDEδ interaction by small molecules impairs Ras localization and signaling. Here we describe in detail the identification and structure guided development of Ras-PDEδ inhibitors targeting the farnesyl binding pocket of PDEδ with nanomolar affinity. We report kinetic data that characterize the binding of the most potent small molecule ligands to PDEδ and prove their binding to endogenous PDEδ in cell lysates. The PDEδ inhibitors provide promising starting points for the establishment of new drug discovery programs aimed at cancers harboring oncogenic K-Ras.
