5068-20-2Relevant articles and documents
SYNTHESIS STRATEGY FOR GAP PROTECTING GROUP
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Paragraph 0017; 0047, (2020/08/22)
The present invention relates to a novel synthesis method to form particular molecules. These molecules have multiple uses, most notably in the field of protecting groups used throughout organic and synthetic chemistry. The disclosed method is safer, more
SYSTEM AND METHOD FOR SOLUTION PHASE GAP PEPTIDE SYNTHESIS
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Paragraph 00056; 00060, (2017/07/14)
Disclosed is a system and method for Fmoc/tBu solution-phase peptide synthesis including the development of a new benzyl-type GAP protecting group, and related uses thereto. This novel GAP protecting group is utilized in place of a polymer support, facilitating C to N Fmoc peptide synthesis without chromatography, recrystallization, or polymer supports. The GAP group can be added and removed in high yield.
Palladium-catalyzed air-based oxidative coupling of arylboronic acids with H-phosphine oxides leading to aryl phosphine oxides
Fu, Tingting,Qiao, Hongwei,Peng, Zhimin,Hu, Gaobo,Wu, Xueji,Gao, Yuxing,Zhao, Yufen
, p. 2895 - 2902 (2014/05/06)
We present a novel and highly efficient methodology that allows for the construction of C-P bonds via the palladium-catalyzed air-based oxidative coupling of various commercially available arylboronic acids with easily oxidized H-phosphine oxides leading to valuable aryl phosphine oxides, particularly triarylphosphine oxides, with the use of air as the green oxidant, broad substrate applicability and good to excellent yields. The described catalytic system should be an efficient complement to the Chan-Lam type reaction and be useful in synthetic programs. This journal is the Partner Organisations 2014.