5069-69-2

Usage

Uses

Used in Pharmaceutical Industry:
6-[(3-chlorobenzyl)sulfanyl]-5H-purine is used as a potential pharmaceutical agent for its possible role in the development of new drugs. 6-[(3-chlorobenzyl)sulfanyl]-5H-purine's structure may allow it to interact with biological targets, such as enzymes or receptors, which could be leveraged for therapeutic purposes.
Used in Agricultural Applications:
In agriculture, 6-[(3-chlorobenzyl)sulfanyl]-5H-purine may be utilized as a component in the development of agrochemicals. Its unique chemical properties could be employed to create compounds that influence plant growth or protect against pests and diseases.
Used in Materials Science:
6-[(3-chlorobenzyl)sulfanyl]-5H-purine could be explored in materials science for its potential to contribute to the creation of new materials with specific properties. 6-[(3-chlorobenzyl)sulfanyl]-5H-purine's ability to form complexes or interact with other molecules might be harnessed in the design of advanced materials for various applications.

Upstream product

• 157930-09-1 6-Mercaptopurine 
• 766-80-3 1-bromomethyl-3-chlorobenzene 

Relevant academic research and scientific papers

Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no known cure. Aggregates of the nuclear protein TDP-43 have been recognized as a hallmark of proteinopathy in both familial and sporadic cases of ALS. Post-translational modifications of this protein, include hyperphosphorylation, cause disruption of TDP-43 homeostasis and as a consequence, promotion of its neurotoxicity. Among the kinases involved in these changes, cell division cycle kinase 7 (CDC7) plays an important role by directly phosphorylating TDP-43. In the present manuscript the discovery, synthesis, and optimization of a new family of selective and ATP-competitive CDC7 inhibitors based on 6-mercaptopurine scaffold are described. Moreover, we demonstrate the ability of these inhibitors to reduce TDP-43 phosphorylation in both cell cultures and transgenic animal models such as C. elegans and Prp-hTDP43 (A315T) mice. Altogether, the compounds described here may be useful as versatile tools to explore the role of CDC7 in TDP-43 phosphorylation and also as new drug candidates for the future development of ALS therapies.

CDC-7-INHIBITOR COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS

The present invention relates to a series of substituted purine derivatives capable of inhibiting CDC7 kinase activity and, as such, suitable for use in the treatment of neurological diseases such as, inter alia, Alzheimer's disease, amyotrophic lateral sclerosis or frontotemporal dementia, involving hyperphosphorylation of TDP-43 and the subsequent formation of aggregates, induced by CDC7.